CAS Number 104344-23-2, Bisoprolol Fumarate or Bisoprolol Hemifumarate BP Ph Eur USP EP IP Grade Manufacturers Exporters
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CAS Number 104344-23-2, Bisoprolol Fumarate or Bisoprolol Hemifumarate BP Ph Eur USP EP IP Grade Manufacturer Exporter
For Properties Specifications of Bisoprolol Fumarate or Bisoprolol Hemifumarate Click Properties, Specifications of Bisoprolol Fumarate or Bisoprolol Hemifumarate Manufacturer.
For Uses of Bisoprolol Fumarate or Bisoprolol Hemifumarate Click Uses of Bisoprolol Fumarate or Bisoprolol Hemifumarate Manufacturer.
For For SDS MSDS Sheet of Bisoprolol Fumarate or Bisoprolol Hemifumarate Click SDS Safety Data Sheet MSDS Sheet of Bisoprolol Fumarate or Bisoprolol Hemifumarate Manufacturer.
The Properties and Specifications of Bisoprolol Fumarate or Bisoprolol Hemifumarate:
Bisoprolol Fumarate USP Grade:
(C18H31NO4)2-C4H4O4 --- 766.96
2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-,(±)-, (E)-2-butenedioate (2:1) (salt).
(±)-1-[[α-(2-Isoproproxyethoxy)-p-tolyl]oxy]-3-(isopropylamino)-2-propanol fumarate (2:1) (salt) CAS 104344-23-2
UNII: UR59KN573L
UNII: Y41JS2NL6U
Bisoprolol Fumarate contains not less than 97.5 percent and not more than 102.0 percent of (C18H31NO4)2-C4H4O4 calculated on the anhydrous basis.
Packaging and storage: Preserve in tight, light-resistant containers. Store at controlled room temperature.
Identification:
A: Infrared Absorption.
B: The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.
Specific rotation: between –2° and +2°.
Test solution: 10 mg per mL, in methanol.
Water Determination: not more than 0.5%.
Residue on ignition: not more than 0.1%.
Chromatographic purity: To pass the test.
Content of fumaric acid: To pass the test.
Assay: To pass the test by Chromatography.
Bisoprolol Fumarate BP Ph Eur Grade:
C40H66N2O12 – 767 --- CAS 104344-23-2
Action and use: Beta-adrenoceptor antagonist.
DEFINITION
(2RS)-1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]propan-2-ol fumarate.
Content: 99.0 per cent to 101.0 per cent (anhydrous substance).
CHARACTERS
Appearance: White or almost white, slightly hygroscopic powder.
Solubility: Very soluble in water, freely soluble in methanol.
IDENTIFICATION
Infrared absorption spectrophotometry.
TESTS
Related substances: To pass the test by Liquid chromatography.
Water: Maximum 0.5 per cent, determined on 1.000 g.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
STORAGE
In an airtight container, protected from light.
Bisoprolol Fumarate is also offered in EP IP Grade.
The Uses of Bisoprolol Fumarate or Bisoprolol Hemifumarate:
Bisoprolol fumarate is a cardioselective beta-blocker used to treat high blood pressure (hypertension) and congestive heart failure. It works by blocking specific nerve impulses, which relaxes blood vessels and slows your heart rate. This reduces the strain on your heart and lowers your cardiovascular risks.
The MSDS-SDS Hazard Statement of Bisoprolol Fumarate or Bisoprolol Hemifumarate:
Bisoprolol Fumarate or Bisoprolol Hemifumarate SDS, Safety Data Sheet
MSDS
1. Product Identification
Product Name/Synonyms: Bisoprolol Fumarate or Bisoprolol Hemifumarate.
CAS No.: 104344-23-2
EINECS EC Number: 600-557-5
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, oral Category 4
Labeling according to Regulation (EC) No 1272/2008
GHS Label Elements Irritant |
Signal Words: Warning
Hazard statements:
H302: Harmful if swallowed.
Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P270: Do not eat, drink or smoke when using this product.
P273: Avoid release to the environment.
P330: Rinse mouth.
P362: Take off contaminated clothing and wash before reuse.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P332+313: If skin irritation occurs: Get medical advice/attention.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/ attention.
P501: Dispose of contents/container to authorized agents only.
3. Composition/Information on Ingredients
Product Name/Synonyms: Bisoprolol Fumarate or Bisoprolol Hemifumarate.
CAS No.: 104344-23-2
EINECS EC Number: 600-557-5
4. First Aid Measures
Inhalation:Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep person warm and quiet; get medical attention.
Ingestion: Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact: Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reusing. Thoroughly clean shoes before reusing them. Get medical attention if irritation develops.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention.
Notes to Physician: Treat symptomatically.
5. Fire Fighting Measures
Fire: It is not considered to be a fire hazard. However, it will burn at high temperature.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemicals, or carbon dioxide. Avoid solid water jets. Use water spray to cool fire-exposed containers.
Special hazards arising from the substance or mixture: Carbon oxides, Nitrogen oxides (NOx), Fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Use personal protective equipment. Ventilate area of leak or spill. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment, cleanup procedures and Storage: Contain spilled material. Pick up spills and place them in a suitable container for reclamation or disposal.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wear personal protective equipment. Avoid ingestion and inhalation. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original containers. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Room temperature. Protected from light. Recommended in a cool and dark place, <15C. Short term shipping may be ambient.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: None established.
Ventilation System: In general, dilution ventilation is a satisfactory health hazard control for this substance. However, if conditions of use create discomfort for the worker, use a local exhaust.
Personal Respirators (NIOSH Approved): Not expected to require personal respirator usage. For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g., lubricants, cutting fluids, glycerin, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection:Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
9. Physical and Chemical Properties
Appearance: White or almost white, slightly hygroscopic powder.
Odor: Not data found.
Odor threshold: Not data found.
pH: Not data found.
Relative density: Not data found.
Boiling Point: Not data found.
Melting Point: Not data found.
Flash point: Not data found.
Auto-ignition temperature: Not data found.
Decomposition temperature: Not data found.
Upper/lower flammability or explosive limits: Not data found.
Vapor pressure: Not data found.
Vapor density: Not data found.
Evaporation rate: Not data found.
Flammability (solid, gas): Not data found.
Partition coefficient: n-octanol/water: Not data found.
Solubility: Very soluble in water, freely soluble in methanol.
Viscosity: Not data found.
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: May produce oxides of nitrogen and carbon along with fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Heat, flame, ignition sources, dusting, and incompatibles.
11. Toxicological Information
Toxicity Data: LD50 (Rat): 940 mg/kg.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Mutagenic Effects: Not data found.
Reproductive Effects: Not data found.
Developmental Effects: Not data found.
Environmental Fate: Not data found.
Persistence and degradability: Not data found.
Bioaccumulative potential: Not data found.
Mobility in soil: Not data found.
PBT and vPvB assessment: Not data found.
13. Disposal Considerations
Whatever cannot be saved for recovery, or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. Dispose of containers and unused material in accordance with legal requirements.
14. Transport Information
Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
Sea Transport IMDG/IMO: Not regulated.
Air Transport IATA/ICAO: Not regulated.
15. Regulatory Information
USA:
SARA 311/312 Hazardous Categorization: Acute Health Hazard. See section 2.
California Proposition 65: This product does not contain any Proposition 65 chemicals.
16. Other Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Anmol Chemicals Industries Pvt. Ltd. is an off-shoot of Anmol Chemicals and Anmol Chemicals & Pharmaceuticals, Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals Industries Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Bisoprolol Fumarate or Bisoprolol Hemifumarate Structure
CAS Number 104344-23-2, Bisoprolol Fumarate or Bisoprolol Hemifumarate Manufacturer Exporter
ANMOL CHEMICALS INDUSTRIES Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: 91-22-65290110
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 23-may-26
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