CAS Number 151767-02-1, Montelukast Sodium USP IP EP BP Ph Eur Grade Manufacturers Exporters
------ 
CAS Number 151767-02-1, Montelukast Sodium USP IP EP BP Ph Eur Manufacturer Exporter
For Properties Specifications of Montelukast Sodium Click Properties, Specifications of Montelukast Sodium Manufacturer.
For Uses of Montelukast Sodium Click Uses of Montelukast Sodium Manufacturer.
For For SDS MSDS Sheet of Montelukast Sodium Click SDS Safety Data Sheet MSDS Sheet of Montelukast Sodium Manufacturer.
The Properties and Specifications of Montelukast Sodium:
Montelukast Sodium BP Ph Eur Grade:
C35H35ClNNaO3S --- 608 --- CAS 151767-02-1
Action and use: Leukotriene CysLT1 receptor antagonist; treatment of asthma.
DEFINITION
Sodium [1-[[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetate.
Content: 98.0 per cent to 102.0 per cent (anhydrous substance).
CHARACTERS
Appearance: White or almost white, hygroscopic powder.
Solubility: Freely soluble in water and in methylene chloride, freely soluble to very soluble in ethanol (96 per cent).
IDENTIFICATION
A. Infrared absorption spectrophotometry.
B. Enantiomeric purity.
C. Ignite 0.1 g in a crucible until an almost white residue is obtained. Take up the residue in 2 mL of water and filter. The filtrate gives reaction of sodium.
TESTS
Enantiomeric purity: To pass the test by liquid chromatography.
Related substances: To pass the test by liquid chromatography.
Water: Maximum 4.0 per cent, determined on 0.300 g.
Montelukast Sodium USP Grade Specifications:
C35H35ClNNaO3S --- 608.17
Cyclopropaneacetic acid, 1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-, sodium salt, [R-,(E)]-;
Sodium 1-[[[(R)-m-[(E)-2-(7-chloro-2-quinolyl)vinyl]-α-[o-(1-hydroxy-1-methylethyl)phenethyl]benzyl]thio]-methyl]cyclopropaneacetate CAS 151767-02-1
C35H36ClNO3S --- 586.18
Montelukast CAS 158966-92-8
UNII: U1O3J18SFL
UNII: MHM278SD3E
DEFINITION
Montelukast Sodium contains NLT 98.0% and NMT 102.0% of C35H35ClNNaO3S, calculated on the anhydrous and solvent-free basis.
IDENTIFICATION
A. Infrared Absorption
B. Identification Tests—General, Sodium
C. Meets the requirements of the test for Enantiomeric Purity.
Organic Impurities: To pass the test by chromatography.
Enantiomeric purity: To pass the test by chromatography.
Water Determination: NMT 4.0%
We also manufacture Montelukast Sodium EP IP grade.
The Uses of Montelukast Sodium:
Montelukast is commonly used for the long-term treatment of asthma and to prevent symptoms of exercise-induced asthma. Montelukast is also used to help control the symptoms of allergies such as sneezing, stuffy, runny, and itchy nose.
The MSDS-SDS Hazard Statement of Montelukast Sodium:
Montelukast Sodium SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 14-Sept-24
1. PRODUCT DESCRIPTION
Product Name & Other Names: Montelukast Sodium.
CAS Number: 151767-02-1
EINECS EC Number: 604-813-7
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. HAZARD IDENTIFICATION
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements None |
Signal Words: None
Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Product Name & Other Names: Montelukast Sodium.
CAS Number: 151767-02-1
EINECS EC Number: 604-813-7
4. FIRST AID MEASURES
Always get medical attention after the first aid is over.
Emergency and First Aid Procedures:
Eyes - Flush with water for at least 15 minutes, raising and lowering eyelids occasionally. Get medical attention if irritation persists.
Skin - Thoroughly wash exposed area for at least 15 minutes. Remove contaminated clothing. Launder contaminated clothing before reuse. Get medical attention if irritation persists.
Ingestion - If swallowed, if conscious, give plenty of water. Immediately call a physician.
Inhalation - Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep a person warm, quiet, and get medical attention.
5. FIREFIGHTING PROCEDURES
Extinguisher Media: Use water spray, alcohol-resistant foam, dry chemical, Aor carbon dioxide. Avoid solid water jet as it can scatter the fire.
Special Fire fighting Procedures: Firefighters should wear full protective equipment and NIOSH approved self-contained breathing apparatus.
Unusual Fire and Explosion Hazards: Heated to decomposition, however, toxic oxides of sulfur, chlorine compounds, oxides of nitrogen and oxides of carbon along with sodium compounds and fumes may be evolved.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
6. SPILL OR LEAK PROCEDURES
Personal precautions, protective equipment, and emergency procedures: Ventilate area of spill. Avoid creating dust. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.
7. SPECIAL PRECAUTIONS
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Provide appropriate exhaust ventilation at places where dust is formed. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like Strong oxidizing agents. Storage: Room Temperature. Light Sensitive. Hygroscopic.
8. SPECIAL PROTECTION INFORMATION
Exposure limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Respiratory Protection (Specify Type): None needed under normal conditions of use with adequate ventilation.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. PHYSICAL DATA
Physical State: White to almost white powder or crystals.
Odor: No data found.
Odor threshold: No data found.
pH: No data found.
Relative density: No data found.
Melting Point: 115C literature.
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Soluble in water and DMSO.
Viscosity: No data found.
10. REACTIVITY DATA
Stability: Stable.
Conditions to Avoid: Dust generation, Incompatibles
Incompatibility (Materials to Avoid): Strong oxidizing agents.
Hazardous Decomposition Products: Oxides of sulfur, chlorine compounds, nitrogen, and carbon along with sodium compounds and fumes.
Hazardous Polymerization: Will not occur.
11. TOXICITY DATA
Toxicity Data: No data found.
Carcinogenicity: Not listed as carcinogen by IARC, ACGIH, OSHA and NTP.
Mutagenic Effects: No data found.
Developmental Toxicity: No data found.
Reproductive Effects: No data found.
12. ECOLOGICAL DATA
Toxicity to fish, daphnia, and other aquatic invertebrates: No data found.
Persistence and Degradability: No data found.
Mobility: No data found.
Results of PBT and vPvB assessment: No data available for assessment.
13. DISPOSAL INFORMATION
Waste Disposal Methods: Dispose in accordance with all applicable regulations.
14. TRANSPORT INFORMATION
DOT (USA) & ADT/RID Europe: Not controlled.
IMDG & IATA: Not controlled.
15. REGULATORY INFORMATION
USA Regulations:
SARA 311/312 Hazard Categories: See section 2.
Disclaimer:
**************************
Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
**************************
Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Montelukast Sodium Structure
CAS Number 151767-02-1, Montelukast Sodium Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 11-dec-24
We manufacture: