CAS Number 518-47-8, Fluorescein Sodium or Fluorescein Disodium BP Ph Eur USP Grade Manufacturers Exporters
------ 
CAS Number 518-47-8, Fluorescein Sodium or Fluorescein Disodium BP Ph Eur USP Manufacturer Exporter
For Properties Specifications of Fluorescein Sodium or Fluorescein Disodium Click Properties, Specifications of Fluorescein Sodium or Fluorescein Disodium Manufacturer.
For Uses of Fluorescein Sodium or Fluorescein Disodium Click Uses of Fluorescein Sodium or Fluorescein Disodium Manufacturer.
For For SDS MSDS Sheet of Fluorescein Sodium or Fluorescein Disodium Click SDS Safety Data Sheet MSDS Sheet of Fluorescein Sodium or Fluorescein Disodium Manufacturer.
The Properties and Specifications of Fluorescein Sodium or Fluorescein Disodium:
Fluorescein Sodium BP Ph Eur Grade Specifications:
Soluble Fluorescein
C20H10Na2O5 --- 376.3 CAS 518-47-8
Action and use: Detection of corneal lesions, retinal angiography and pancreatic function testing.
CHARACTERS
Appearance: Orange-red, fine powder, hygroscopic.
Solubility: Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in hexane and in methylene chloride.
IDENTIFICATION
First identification: B, D
Second identification: A, C, D
A. Dilute 0.1 mL of solution S (see Tests) to 10 mL with water. The solution shows yellowish-green fluorescence. The fluorescence disappears on addition of 0.1 mL of dilute hydrochloric acid and reappears on addition of 0.2 mL of dilute sodium hydroxide solution.
B. Infrared absorption spectrophotometry.
C. The absorption by a piece of filter paper of 0.05 mL of the solution prepared for identification A (before the addition of dilute hydrochloric acid) colours the paper yellow. On exposing the moist paper to bromine vapour for 1 min and then to ammonia vapour, the colour becomes deep pink.
D. Ignite 0.1 g in a porcelain crucible. Dissolve the residue in 5 mL of water and filter. 2 mL of the filtrate gives reaction (a) of sodium.
TESTS
Solution S: Dissolve 1.0 g in carbon dioxide-free water prepared from distilled water and dilute to 50 mL with the same solvent.
Appearance of solution: Solution S is clear and orange-yellow with yellowish-green fluorescence.
pH:7.0 to 9.0 for solution S.
Related substances: To pass the test by liquid chromatography.
Chlorides: Maximum 0.25 per cent.
Sulfates: Maximum 1.0 per cent.
Zinc: Dilute 5 mL of solution S to 10 mL with water. Add 2 mL of hydrochloric acid, filter and add 0.1 mL of potassium ferrocyanide solution. No turbidity or precipitate is formed immediately.
Loss on drying: Maximum 10.0 per cent, determined on 1.000 g by drying in an oven at 105C.
Fluorescein Sodium USP Grade Specifications:
C20H10Na2O5 --- 376.27
Benzoic acid, 2-(6-hydroxy-3-oxo-3H -xanthene-9-yl), sodium salt (1:2);
Fluorescein disodium salt CAS 518-47-8
UNII: 93X55PE38X
UNII: TPY09G7XIR
DEFINITION
Fluorescein Sodium contains NLT 90.0% and NMT 102.0% of fluorescein sodium (C20H10Na2O5), calculated on the anhydrous basis.
IDENTIFICATION
A. A solution is strongly fluorescent, even in extreme dilution. The fluorescence disappears when the solution is made acid and reappears when the solution is again made alkaline.
B. Identification Tests—General, Sodium: The residue remaining after incineration meets the requirements.
C. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
Zinc:
Sample solution: 10 mg/mL of Fluorescein Sodium in a saturated solution of sodium chloride.
Analysis: To 10 mL of Sample solution add 2 mL of 3 N hydrochloric acid. Shake well, filter, and add 1 mL of potassium ferrocyanide to the filtrate.
Acceptance criteria: No turbidity is produced.
Acriflavine:
Sample solution: 2 mg/mL of Fluorescein Sodium in water. Swirl the mixture, and filter.
Analysis: To the Sample solution add a few drops of 100-mg/mL sodium salicylate solution.
Acceptance criteria: No precipitate is formed.
Organic Impurities: To pass the test by chromatography.
Water Determination: NMT 17.0%
Packaging and Storage: Preserve in tight containers.
The Uses of Fluorescein Sodium or Fluorescein Disodium:
Fluorescein sodium or Acid Yellow 73, the sodium salt of fluorescein, is used extensively as a diagnostic tool in the field of ophthalmology and optometry. It is water-soluble form of fluorescein. Odorless and almost tasteless.The MSDS-SDS Hazard Statement of Fluorescein Sodium or Fluorescein Disodium:
Fluorescein Sodium or Acid Yellow 73 SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 03-Nov-24
1. PRODUCT DESCRIPTION
Product Name & Other Names: Fluorescein Sodium or Acid Yellow 73.
CAS Number: 518-47-8
EINECS EC Number: 208-253-0
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. HAZARD IDENTIFICATION
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements None |
Signal Words: None
Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Product Name & Other Names: Fluorescein Sodium or Acid Yellow 73.
CAS Number: 518-47-8
EINECS EC Number: 208-253-0
4. FIRST AID MEASURES
Always get medical attention after the first aid is over.
Emergency and First Aid Procedures:
Eyes - Flush with water for at least 15 minutes, raising and lowering eyelids occasionally. Get medical attention if irritation persists.
Skin - Thoroughly wash exposed area for at least 15 minutes. Remove contaminated clothing. Launder contaminated clothing before reuse. Get medical attention if irritation persists.
Ingestion - If swallowed, if conscious, give plenty of water. Immediately call a physician. Never give anything by mouth to an unconscious person.
Inhalation - Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Get medical attention.
5. FIREFIGHTING PROCEDURES
Extinguisher Media: Water spray. Carbon dioxide (CO2). Dry chemical. alcohol-resistant foam. Avoid solid water jet as it can scatter the fire.
Flammable Limits in Air % by Volume: N/A
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.
6. SPILL OR LEAK PROCEDURES
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.
7. SPECIAL PRECAUTIONS
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Room temperature. Preferably refrigerate.
8. SPECIAL PROTECTION INFORMATION
Exposure Guidelines: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies. Better keep it under 10 mg/m3
Respiratory Protection (Specify Type): None needed under normal conditions of use with adequate ventilation. NIOSH approved equipment should be worn if PELs are exceeded.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. PHYSICAL DATA
Appearance: Orange-red powder. Hygroscopic.
Odor: Odorless.
Odor threshold: No data found.
pH: No data found.
Relative density: about 1.6
Melting point/freezing point: >300C literature.
Initial boiling point and boiling range: 663C literature.
Flash point: 217C literature.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Soluble in water
Viscosity: No data found.
Molecular Weight: 376.27
Molecular Formula: C20H10Na2O5
10. REACTIVITY DATA
Stability: Stable under normal conditions.
Conditions to Avoid: Heat and Strong oxidizing agents. Avoid moisture.
Incompatibility (Materials to Avoid): Strong oxidizing.
Hazardous Decomposition Products: Carbon oxides, Sodium oxide.
Hazardous Polymerization: Will not occur.
11. TOXICITY DATA
LD50 Oral - Rat - 6720 mg/kg.
Carcinogenicity: No product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed human carcinogen by NTP, ACGIH & OSHA. It is a Group 3: Not classifiable as to its carcinogenicity to humans as per IARC.
Teratogenic Effects: No data found.
Mutagenic Effects: No data found.
Reproductive Effects: No data found.
12. ECOLOGICAL DATA
Toxicity to fish: LC50 - Ictalurus catus (catfish) - 2.267 mg/l - 96 h.
Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h.
Persistence and Degradability: Unlikely to persist due to water solubility.
Mobility: Likely to be mobile due to water solubility.
Bioaccumulation/ Accumulation: No data found.
Results of PBT and vPvB assessment: No data available for assessment.
13. DISPOSAL INFORMATION
Waste Disposal Methods: Dispose in accordance with all applicable Federal, State and Local regulations.
14. TRANSPORT INFORMATION
DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
IMDG/IMO: Not dangerous goods.
IATA: Not dangerous goods.
15. REGULATORY INFORMATION
USA:
SARA 311/312 Hazards: None
California Prop. 65 Components: This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.
16. ADDITIONAL INFORMATION
Disclaimer:********************************
Our company provides this MSDS information sheet contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.
********************************
Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Fluorescein Sodium or Fluorescein Disodium Structure
CAS Number 518-47-8, Fluorescein Sodium or Fluorescein Disodium Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 18-nov-24
We manufacture: