CAS Number 59-51-8 or 63-68-3 L-isomer or 348-67-4 D-isomer, Methionine DL-Methionine L-Methionine USP BP Ph Eur FCC Food Grade Manufacturers Exporters
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CAS Number 59-51-8 or 63-68-3 L-isomer or 348-67-4 D-isomer, Methionine DL-Methionine L-Methionine USP BP Ph Eur FCC Food Grade Manufacturer Exporter
For Properties Specifications of Methionine DL-Methionine L-Methionine Click Properties, Specifications of Methionine DL-Methionine L-Methionine Manufacturer.
For Uses of Methionine DL-Methionine L-Methionine Click Uses of Methionine DL-Methionine L-Methionine Manufacturer.
For For SDS MSDS Sheet of Methionine DL-Methionine L-Methionine Click SDS Safety Data Sheet MSDS Sheet of Methionine DL-Methionine L-Methionine Manufacturer.
The Properties and Specifications of Methionine DL-Methionine L-Methionine:
Specifications of DL-Methionine BP Ph Eur Grade:
C5H11NO2S --- 149.2 --- CAS 59-51-8
Action and use: Used in treatment of paracetamol overdose.
DEFINITION
DL-Methionine contains not less than 99.0 per cent and not more than the equivalent of 101.0 per cent of (2RS)-2-amino-4-(methylsulfanyl)butanoic acid, calculated with reference to the dried substance.
CHARACTERS
Almost white, crystalline powder or small flakes, sparingly soluble in water, very slightly soluble in alcohol. It dissolves in dilute acids and in dilute solutions of the alkali hydroxides.
It melts at about 270C (instantaneous method).
IDENTIFICATION
First identification: A, C
Second identification: B, C, D
A. Examine by infrared absorption spectrophotometry, comparing with the spectrum obtained with DL-methionine CRS. Dry the substances at 105C.
B. Examine the chromatograms obtained in the test for related substances. The principal spot in the chromatogram obtained with test solution (b) is similar in position, colour and size to the principal spot in the chromatogram obtained with reference solution (a).
C. Dissolve 2.50 g in 1 M hydrochloric acid and dilute to 50.0 mL with the same acid. The angle of optical rotation is -0.05° to + 0.05°.
D. Dissolve 0.1 g of the substance to be examined and 0.1 g of glycine in 4.5 mL of dilute sodium hydroxide solution. Add 1 mL of a 25 g/L solution of sodium nitroprusside. Heat to 40C for 10 min. Allow to cool and add 2 mL of a mixture of 1 volume of phosphoric acid and 9 volumes of hydrochloric acid. A deep red colour develops.
TESTS
Solution S: Dissolve 1.0 g in carbon dioxide-free water and dilute to 50 mL with the same solvent.
Appearance of solution: Solution S is clear and colourless.
pH: The pH of solution S is 5.4 to 6.1.
Related substances: To pass the test. --- (0.2 per cent).
Chlorides: Dissolve 0.25 g in 35 mL of water. Add 5 mL of dilute nitric acid and 10 mL of silver nitrate solution. Allow to stand protected from light for 5 min. Any opalescence in the solution is not more intense than that in a standard prepared at the same time in the same manner using a mixture of 10 mL of chloride standard solution (5 ppm Cl) and 25 mL of water (200 ppm). Examine the tubes laterally against a black background.
Sulfates: Dissolve 1.0 g in 20 mL of distilled water, heating to 60C. Cool to 10C and filter. 15 mL of the solution complies with the limit test for sulfates (200 ppm).
Loss on drying: Not more than 0.5 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Not more than 0.1 per cent, determined on 1.0 g.
Specifications of Methionine USP Grade:
C5H11NO2S --- 149.21
l-Methionine --- CAS 63-68-3
DEFINITION
Methionine contains NLT 98.5% and NMT 101.5% of l-methionine (C5H11NO2S), calculated on the dried basis.
IDENTIFICATION
Infrared Absorption
ASSAY
To pass the test.
Acceptance criteria: 98.5%–101.5% on the dried basis
Residue on Ignition: NMT 0.4%
Chloride and Sulfate, Chloride:
Acceptance criteria: NMT 0.05%
Chloride and Sulfate, Sulfate:
Acceptance criteria: NMT 0.03 %
Iron: NMT 30 ppm
Related Compounds: To pass the test.
Acceptance criteria: Any secondary spot of the Sample solution is not larger or more intense than the principal spot of the Standard solution.
Individual impurities: NMT 0.5%
Total impurities: NMT 2.0%
Optical Rotation, Specific Rotation:
Acceptance criteria: +22.4° to +24.7°
pH: 5.6–6.1
Loss on Drying: Dry a sample at 105C for 3 h: it loses NMT 0.3% of its weight.
Specifications of DL-Methionine FCC Food Grade:
DL-2-Amino-4-(methylthio)butyric Acid
CH3SCH2CH2CHCOOH NH2
C5H11NO2S Formula weight 149.21
CAS 59-51-8
DESCRIPTION
DL-Methionine occurs as white crystalline platelets or a powder. One gram dissolves in about 30 mL of water. It is soluble in dilute acids and in solutions of alkali hydroxides. It is very slightly soluble in alcohol, and practically insoluble in ether. It is optically inactive. The pH of a 1:100 aqueous solution is between 5.6 and 6.1.
Function: Nutrient.
REQUIREMENTS
Identification: The infrared absorption spectrum of the sample exhibits relative maxima at the same wavelengths as those of a typical spectrum as shown in the section on Infrared Spectra, using the same test conditions as specified therein.
Assay: Not less than 98.5% and not more than 101.5% of C5H11NO2S, calculated on the dried basis.
Lead: Not more than 5 mg/kg.
Loss on Drying: Not more than 0.5%.
Residue on Ignition: Not more than 0.1%.
The Uses of Methionine DL-Methionine L-Methionine:
Methionine is largely used in animal feed
The MSDS-SDS Hazard Statement of Methionine DL-Methionine L-Methionine:
L-Methionine or L-Methionine or (S)-2-Amino-4-(methylmercapto)butyric acid or L-2-Amino-4-(methylthio)butanoic acid SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 11-Dec-24
1. PRODUCT DESCRIPTION
Product Name & Other Names: L-Methionine or L-Methionine or (S)-2-Amino-4-(methylmercapto)butyric acid or L-2-Amino-4-(methylthio)butanoic acid.
CAS Number: 63-68-3 (L-isomer)
EINECS EC Number: 200-562-9 (L-isomer)
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. HAZARD IDENTIFICATION
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements None |
Signal Words: None
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Product Name & Other Names: L-Methionine or L-Methionine or (S)-2-Amino-4-(methylmercapto)butyric acid or L-2-Amino-4-(methylthio)butanoic acid.
CAS Number: 63-68-3 (L-isomer)
EINECS EC Number: 200-562-9 (L-isomer).
4. FIRST AID MEASURES
Always get medical attention after the first aid is over.
Emergency and First Aid Procedures:
Eyes - Flush with water for at least 15 minutes, raising and lowering eyelids occasionally. Get medical attention if irritation persists.
Skin - Thoroughly wash exposed area for at least 15 minutes. Remove contaminated clothing. Launder contaminated clothing before reuse. Get medical attention if irritation persists.
Ingestion - If swallowed, if conscious, give plenty of water. Immediately call a physician.
Inhalation - Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep a person warm, quiet, and get medical attention.
5. FIREFIGHTING PROCEDURES
Extinguisher Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Avoid solid water jet as it can scatter the fire.
Special Fire fighting Procedures: Firefighters should wear full protective equipment and NIOSH approved self-contained breathing apparatus.
Unusual Fire and Explosion Hazards: Heated to decomposition, however, toxic oxides of sulfur, oxides of nitrogen and oxides of carbon along with fumes may be evolved.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
6. SPILL OR LEAK PROCEDURES
Personal precautions, protective equipment, and emergency procedures: Ventilate area of spill. Avoid creating dust. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.
7. SPECIAL PRECAUTIONS
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Provide appropriate exhaust ventilation at places where dust is formed. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents.
8. SPECIAL PROTECTION INFORMATION
Exposure limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Respiratory Protection (Specify Type): None needed under normal conditions of use with adequate ventilation.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
9. PHYSICAL DATA
Physical State: Almost white, crystalline powder or small flakes.
Odor: Faint.
Odor threshold: No data found.
pH: 5.6–6.1
Relative density: about 1.34
Melting Point: 284 °C.
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: 280C - 282C.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility in Water: Soluble in water.
Viscosity: No data found.
10. REACTIVITY DATA
Stability: Stable.
Conditions to Avoid: Dust generation, Incompatibles
Incompatibility (Materials to Avoid): Strong Oxidizing Agents.
Hazardous Decomposition Products: Oxides of sulfur, nitrogen, and carbon along with fumes.
Hazardous Polymerization: Will not occur.
11. TOXICITY DATA
Toxicity Data: LD50 Oral - Rat – >10 g/kg
Carcinogenicity: Not listed as carcinogen by IARC, ACGIH, OSHA and NTP.
Mutagenic Effects: No data found.
Developmental Toxicity: No data found.
Reproductive Effects: No data found.
12. ECOLOGICAL DATA
Toxicity to fish, daphnia, and other aquatic invertebrates:
Toxicity to fish semi-static test LC50 - Danio rerio (zebra fish) - > 3200 mg/l - 96 h.
Toxicity to daphnia and other aquatic invertebrates static test EC50 - Daphnia magna (Water flea) - 324 mg/l - 48 h.
Persistence and Degradability: Likely to degrade.
Mobility: Likely to be mobile due to water solubility.
Results of PBT and vPvB assessment: No data found for assessment.
13. DISPOSAL INFORMATION
Waste Disposal Methods: Dispose in accordance with all applicable regulations. Follow all the pollution control laws.
14. TRANSPORT INFORMATION
DOT (USA) & ADT/RID Europe: Not regulated.
IMDG & IATA: Not regulated.
15. REGULATORY INFORMATION
USA Regulations:
SARA 311/312 Hazard Categories: See section 2.
16. ADDITIONAL INFORMATION
DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals must exercise their judgment in determining its appropriateness for a particular purpose.Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Methionine DL-Methionine L-Methionine Structure
CAS Number 59-51-8 or 63-68-3 L-isomer or 348-67-4 D-isomer, Methionine DL-Methionine L-Methionine Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 11-dec-24
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