CAS Number 148553-50-8, Pregabalin EP IP BP Ph Eur Grade Manufacturers Exporters
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CAS Number 148553-50-8, Pregabalin EP IP BP Ph Eur Manufacturer Exporter
For Properties Specifications of Pregabalin Click Properties, Specifications of Pregabalin Manufacturer.
For Uses of Pregabalin Click Uses of Pregabalin Manufacturer.
For For SDS MSDS Sheet of Pregabalin Click SDS Safety Data Sheet MSDS Sheet of Pregabalin Manufacturer.
The Properties and Specifications of Pregabalin:
Pregabalin BP Ph Eur Grade Specifications:
C8H17NO2 --- 159.2 CASC148553-50-8
Action and use: Antiepileptic.
DEFINITION
(3S)-3-(Aminomethyl)-5-methylhexanoic acid.
Content: 98.0 per cent to 102.0 per cent (anhydrous substance).
CHARACTERS
Appearance: White or almost white powder.
Solubility: Sparingly soluble in water, very slightly soluble in methanol, practically insoluble in heptane.
IDENTIFICATION
A. Infrared absorption spectrophotometry.
B. Examine the chromatograms obtained in the test for enantiomeric purity.
Results The principal peak in the chromatogram obtained with the test solution is similar in retention time to the principal peak in the chromatogram obtained with the reference solution.
Water: Maximum 0.5 per cent, determined on 0.130 g.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
We also supply Pregabalin IP EP Grade.
The Uses of Pregabalin:
Pregabalin or (S)-3-(Aminomethyl)-5-methylhexanoic acid is an anticonvulsant, analgesic, and anxiolytic medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, opioid withdrawal, and generalized anxiety disorder.
The MSDS-SDS Hazard Statement of Pregabalin:
Pregabalin or (S)-3-(Aminomethyl)-5-methylhexanoic Acid
SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 13-Nov-24
1. Product Identification
Product Name & Other Names: Pregabalin or (S)-3-(Aminomethyl)-5-methylhexanoic Acid.
CAS Number: 148553-50-8
EINECS EC Number: 604-639-1
Molecular Formula: C8H17NO2
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Specific target organ toxicity, single exposure; Narcotic effects Category 3, H336
Reproductive toxicity Category 2, H361
Labeling according to GHS USA & Regulation (EC) No 1272/2008
GHS Label Elements  Irritant |
GHS Label Elements |
Signal Words: Danger
Hazard Statements:
H336: May cause drowsiness and dizziness.
H361: Suspected of damaging fertility or the unborn child.
Precautionary Statements:
P202: Do not handle until all safety precautions have been read and understood.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
3. Composition/Information on Ingredients
Product Name & Other Names: Pregabalin or (S)-3-(Aminomethyl)-5-methylhexanoic Acid.
CAS Number: 148553-50-8
EINECS EC Number: 604-639-1
4. First Aid Measures
Inhalation: Remove affected person to fresh air; if normal breathing has not returned within a few minutes after exposure, get medical attention.
Skin: Remove contaminated clothing; wash affected area with soap and water; launder contaminated clothing before reuse. Seek medical attention.
Eyes: Immediately, flush eyes for 15 minutes in clear running water while holding eyelids open; seek medical attention immediately.
Ingestion: Drink two glasses of water followed by milk, milk of magnesia or other non-alcoholic liquids; Do not induce vomiting; seek medical attention immediately.
Physician may treat symptomatically.
5. Fire Fighting Measures
Flammable Limits: No unusual fire or explosion hazards noted. However, it will burn at high temperature.
General Hazards: Contact with eyes causes immediate severe irritation of the eye and eyelids. Product will support combustion.
Extinguishing Media: Carbon dioxide, water fog, dry chemical, chemical foam.
Organics solids, may be ignitable. Keep containers cool by spraying with water. Use extinguishing media appropriate for surrounding fire. Avoid solid water jet as it can scatter the fire.
Fire & Explosion Hazard: May evolve toxic fumes, oxides of carbon (COx), oxides of nitrogen (NOx) under fire conditions.
In case of fire, wear a full face positive-pressure self-contained breathing apparatus and protective suit. Self - contained respiratory equipment; cool containers to prevent pressure buildup and explosion when exposed to extreme heat.
Hazardous Combustion Products: Products of combustion include smoke, toxic fumes, oxides of carbon to include carbon monoxide, nitrogen oxides.
Specific Methods: Cool containers exposed to flames with water until well after the fire is out.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: It may support combustion. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Avoid breathing dust/fumes/gas/mist/vapors/spray. Provide appropriate exhaust ventilation at places where dust is formed. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agent.
8. Exposure Controls/Personal Protection
Engineering Controls: The use of local exhaust ventilation is recommended to control emissions near the source. Provide mechanical ventilation of confined spaces.
Exposure Limits: Not established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: White to off white powder.
Odor: No data found.
Odor threshold: No data found.
pH: Not available.
Relative density: No data found.
Melting/Freezing Point: 176C to 178C literature.
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility in Water: Sparingly soluble in water.
Viscosity: No data found.
10. Stability and Reactivity
Stability: Stable at normal temperatures and operating conditions.
Conditions to Avoid: Avoid excessively high temperatures and contact with strong oxidizing agents.
Incompatibilities: Oxidizing Agent.
Decomposition: Decomposition yields toxic fumes, oxides of carbon (COx), oxides of nitrogen (NOx.
Polymerization: Polymerization will not occur.
11. Toxicological Information
Toxic if swallowed.
Toxicity Data:
LD50 Oral - Rat - >5000 mg/kg
Reproduction: Suspected of damaging fertility or the unborn child.
Carcinogenicity: Not listed as a human carcinogen by OSHA, IARC, ACGIH & NTP.
Remarks on Possible Effects: Dizziness. Fainting. Fever. Weight gain. Anxiety. Irritability. Restlessness. Confusion. Blurred vision. Tremor. Headache. Constipation. Drowsiness. Salivation. Nausea. Vomiting. Heartburn. Sweating. Nervousness. Hallucinations. Seizures. Narcotic effects.
12. Ecological Information
Toxicity to fish: LC50 - Oncorhynchus mykiss (rainbow trout) - >1000 mg/l - 96 h.
Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna (Water flea) - > 1000 mg/l - 48 h.
Results of PBT and vPvB assessment: No data found.
Persistence and degradability: No data found.
Bioaccumulative potential: No data found.
Mobility: No data found.
13. Disposal Considerations
Dispose of it in accordance with Local, State, and Federal Regulations. Follow all the pollution control norms.
14. Transport Information
DOT USA & ADR/RID Europe: No data found.
IATA & IMDG: No data found.
15. Regulatory Information
No additional data is found.
Section 16 - Additional Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Pregabalin Structure
CAS Number 148553-50-8, Pregabalin Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 24-nov-24
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