CAS Number 87333-19-5, Ramipril USP BP Ph Eur Grade Manufacturers Exporters
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CAS Number 87333-19-5, Ramipril USP BP Ph Eur Manufacturer Exporter
For Properties Specifications of Ramipril Click Properties, Specifications of Ramipril Manufacturer.
For Uses of Ramipril Click Uses of Ramipril Manufacturer.
For For SDS MSDS Sheet of Ramipril Click SDS Safety Data Sheet MSDS Sheet of Ramipril Manufacturer.
The Properties and Specifications of Ramipril:
Ramipril USP Grade Specifications:
C23H32N2O5 --- 416.51
Cyclopenta[b]pyrrole-2-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, [2S -[1[R*(R*)],2α,3aβ,6aβ]]-;
(2S ,3aS ,6aS )-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid, 1-ethyl ester
CAS 87333-19-5
UNII: L35JN3I7SJ
DEFINITION
Ramipril contains NLT 98.0% and NMT 102.0% of ramipril (C23H32N2O5 ), calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption
B: The retention time of the major peak of the Sample solution corresponds to that of the Standard solution.
Residue on Ignition: NMT 0.1%
Limit of Palladium: To pass the test by atomic absorption spectrophotometry. --- 20 ppm.
Organic Impurities: To pass the test by chromatography.
Optical Rotation, Specific Rotation:
Sample solution: 10 mg/mL, in 0.1 M methanolic hydrochloric acid
Acceptance criteria: +32.0° to +38.0°, at 20°
Loss on Drying: Dry under vacuum at a pressure not exceeding 5 mm of mercury at 60C for 6 h. Acceptance criteria: NMT 0.2%
Ramipril BP Ph Eur Grade Specifications: (Offered grade)
C23H32N2O5 --- 416.5 CAS 87333-19-5
Action and use: Angiotensin converting enzyme inhibitor.
DEFINITION
(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid.
Content: 98.0 per cent to 101.0 per cent (dried substance).
CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Sparingly soluble in water, freely soluble in methanol.
IDENTIFICATION
A. Specific optical rotation.
B. Infrared absorption spectrophotometry.
TESTS
Appearance of solution: The solution is clear and colourless.
Dissolve 0.1 g in methanol and dilute to 10 mL with the same solvent.
Specific optical rotation: + 32.0 to + 38.0 (dried substance).
Related substances: To pass the test by Liquid chromatography.
Palladium: Maximum 20 ppm.
Loss on drying: Maximum 0.2 per cent, determined on 1.000 g by drying in an oven under high vacuum at 60C for 4 h.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Storage: Protected from light.
The Uses of Ramipril:
Ramipril is an ACE inhibitor type medication used to treat high blood pressure, heart failure, and diabetic kidney disease.
The MSDS-SDS Hazard Statement of Ramipril:
Ramipril SDS, Safety Data Sheet
MSDS Sheet, Material safety Data Sheet 13-Nov-24
1. Product Identification
Product Name & Other Names: Ramipril.
CAS No.: 87333-19-5
EINECS: EC Number: 642-904-3 or 1312995-182-4
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Reproductive toxicity Category 1B, (H360)
Labeling according to Regulation (EC) No 1272/2008
GHS Label Elements  Health Hazard |
Signal word: Danger.
Hazard statements:
H360 May damage fertility. May damage the unborn child.
Precautionary statements:
P210: Keep away from heat/sparks/open flames/hot surfaces – No smoking.
P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P280 Wear protective gloves/ eye protection/ face protection.
P305+ P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
3. Composition/Information on Ingredients
Product Name & Other Names: Ramipril.
CAS No.: 87333-19-5
EINECS: EC Number: 642-904-3 or 1312995-182-4
Molecular Weight: 416.52
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
Note to Physician: Symptomatic and supportive treatment is recommended.
5. Fire Fighting Measures
Flammability of the Product: It is an organic material. Forms explosive mixtures with air on intense heating.
Products of Combustion: It emits Carbon oxides, Nitrogen oxides and fumes when heated.
Fire Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Avoid solid water jet as it can scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Eliminate all sources of ignition. Avoid dust-mist formation. Avoid breathing dust. Ensure adequate ventilation. Use appropriate tools to put the spilled material in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and disposing of it according to local and regional authority requirements. Beware of vapors accumulating to form explosive concentrations.
Large Spill: Eliminate all sources of ignition. Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Refrigerated (0-10C). Heat Sensitive.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: White to almost white powder or crystals.
Odor: No data found.
Odor threshold: No data found.
pH: No data found.
Relative density: No data found.
Boiling Point: 109C literature.
Melting Point: 23C-25C literature.
Flash Point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Soluble in methanol.
Viscosity: No data found.
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage. Hygroscopic, Air sensitive, Light sensitive. Forms explosive mixtures with air on intense heating.
Hazardous Decomposition Products: It emits Carbon oxides, Nitrogen oxides and fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents, Heat.
Conditions to Avoid: Heat, Incompatibles.
11. Toxicological Information
Toxicity to Animals:
ORAL (LD50): >10000 mg/kg (Rat).
Carcinogenic Effects: Not a reported carcinogen.
Mutagenic Effects: No data found.
Teratogenic Effects: No data found.
Developmental Toxicity: Damage to fetus possible(N-methyl-2-pyrrolidone).
12. Ecological Information
BOD5 and COD: No data found.
Environmental Toxicity: No data found.
Results of PBT and vPvB assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Follow all the pollution control laws.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
IMDG/IMO: Not dangerous goods.
IATA: Not dangerous goods.
15. Regulatory Information
USA:
SARA 311/312 Hazards: See section 2.
California Prop. 65 Components: Not listed.
16. Other Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Ramipril Structure
CAS Number 87333-19-5, Ramipril Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 13-nov-24
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