CAS Number 137-08-6, Calcium Pantothenate USP BP EP Ph Eur IP FCC Food Grade Manufacturers Exporters
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CAS Number 137-08-6, Calcium Pantothenate USP BP EP Ph Eur IP FCC Food Grade Manufacturer Exporter
For Properties Specifications of Calcium Pantothenate Click Properties, Specifications of Calcium Pantothenate Manufacturer.
For Uses of Calcium Pantothenate Click Uses of Calcium Pantothenate Manufacturer.
For For SDS MSDS Sheet of Calcium Pantothenate Click SDS Safety Data Sheet MSDS Sheet of Calcium Pantothenate Manufacturer.
The Properties and Specifications of Calcium Pantothenate:
Calcium Pantothenate BP Ph Eur
Ph. Eur.
C18H32CaN2O10 --- 476.5 --- CAS 137-08-6
Action and use: Component of vitamin B.
DEFINITION
Calcium pantothenate contains not less than 98.0 per cent and not more than the equivalent of 101.0 per cent of calcium bis[3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate], calculated with reference to the dried substance.
CHARACTERS
A white or almost white powder, slightly hygroscopic, freely soluble in water, slightly soluble in alcohol.
IDENTIFICATION
A. Specific optical rotation.
B. Examine the chromatograms.
C. To 1 mL of solution S (see Tests) add 1 mL of dilute sodium hydroxide solution and 0.1 mL of copper sulfate solution. A blue colour develops.
D. It gives reaction (a) of calcium.
TESTS
Solution S: Dissolve 2.50 g in carbon dioxide-free water and dilute to 50.0 mL with the same solvent.
Appearance of solution: Solution S is clear and colourless.
pH: The pH of solution S is 6.8 to 8.0.
Specific optical rotation: + 25.5 to + 27.5, determined on solution S and calculated with reference to the dried substance.
3-Aminopropionic acid: To pass the test.
Chlorides: 5 mL of solution S diluted to 15 mL with water complies with the limit test for chlorides (200 ppm).
Loss on drying: Not more than 3.0 per cent, determined on 1.000 g by drying in an oven at 105C.
Calcium Pantothenate USP Grade
C18H32CaN2O10 --- 476.53
-Alanine, N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, calcium salt (2:1), (R)-.
Calcium D-pantothenate (1:2) --- CAS 137-08-6
Calcium Pantothenate is the calcium salt of the dextrorotatory isomer of pantothenic acid. It contains not less than 5.7 percent and not more than 6.0 percent of nitrogen (N), and not less than 8.2 percent and not more than 8.6 percent of calcium (Ca), both calculated on the dried basis.
Identification:
A: Infrared Absorption.
B: A solution (1 in 20) responds to the tests for Calcium.
Specific rotation: between +25.0 and +27.5 .
Test solution: 50 mg per mL, in water.
Alkalinity: Dissolve 1.0 g in 15 mL of carbon dioxide-free water in a small flask. As soon as solution is complete, add 1.0 mL of 0.10 N hydrochloric acid, then add 0.05 mL of phenolphthalein, and mix: no pink color is produced within 5 seconds.
Loss on drying: Dry it at 105C for 3 hours: it loses not more than 5.0% of its weight.
Heavy metals: ---: the limit is 0.002%.
Nitrogen content: To pass the test.
Content of calcium: Dissolve about 800 mg of Calcium Pantothenate, accurately weighed, in 150 mL of water containing 2 mL of 3 N hydrochloric acid. Add 15 mL of 1 N sodium hydroxide and 300 mg of hydroxy naphthol blue, and titrate with 0.05 M edetate disodium until the solution is a distinct blue in color. Each mL of 0.05 M edetate disodium is equivalent to 2.004 mg of Ca.
Calcium Pantothenate FCC Food Grade
D-Calcium Pantothenate; Dextro Calcium Pantothenate
HOCH2C(CH3)2CH(OH)CONH(CH2)2COO Ca2
C18H32CaN2O10 Formula weight 476.54
CAS 137-08-6
DESCRIPTION
Calcium Pantothenate occurs as a slightly hygroscopic, white powder. It is the calcium salt of the dextrorotatory isomer of pantothenic acid. It is stable in air. One gram dissolves in about 3 mL of water. It is soluble in glycerin, but is practically insoluble in alcohol, in chloroform, and in ether.
Function: Nutrient.
REQUIREMENTS
Identification:
A. A 1:20 aqueous solution gives positive tests for Calcium.
B. The infrared absorption spectrum of a potassium bromide dispersion of the sample, previously dried at 105C for 3 h, exhibits relative maxima at the same wavelengths as those of a similar preparation of USP Calcium Pantothenate.
C. Boil 50 mg of sample in 5 mL of 1 N sodium hydroxide for 1 min, cool, and add 5 mL of 1 N hydrochloric acid and 2 drops of ferric chloride. A strong yellow color appears.
Assay: Not less than 97.0% and not more than 103.0% of Dextrorotatory Calcium Pantothenate (C18H32CaN2O10) after drying.
Alkalinity: Passes test.
Alkaloids: Passes test.
Calcium Content: Not less than 8.2% and not more than 8.6% of calcium (Ca) after drying.
Lead: Not more than 2 mg/kg.
Loss on Drying: Not more than 5.0%.
Optical (Specific) Rotation 25C: Between +25.0° and +27.5° after drying.
Calcium Pantothenate IP EP Grade
Calcium Pantothenate or Calcium D-pantothenate is also available as IP grade.
The Uses of Calcium Pantothenate:
Calcium Pantothenate is a dietary supplement. It is used in the treatment of deficiency of Pantothenic Acid (Vitamin B5). It is also used lower the level of bad cholesterol in the blood and treat hair loss caused due to the deficiency of Vitamin B5.
The MSDS-SDS Hazard Statement of Calcium Pantothenate:
Calcium pantothenate or Calcium D-pantothenate SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 22-Nov-24
1. Product Identification
Product Name & Other Names: Calcium pantothenate or Calcium D-pantothenate.
CAS No.: 137-08-6
EINECS EC Code number: 205-278-9
Relevant uses and uses advised against (if any): Laboratory Chemicals and Industrial Manufacturing Use.
Supplier: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements NONE |
Signal Word: None
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
3. Composition/Information on Ingredients
Product Name/ Synonyms: Calcium pantothenate or Calcium D-pantothenate.
CAS No.: 137-08-6
EINECS EC Code number: 205-278-9
4. First Aid Measures
Always seek medical advice after the first aid treatment.
Inhalation: Remove to fresh air. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases, and groin. Cold water may be used. Cover the irritated skin with an emollient. If irritation persists, seek medical attention.
Eye Contact: Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention.
5. Fire Fighting Measures
Fire: Not considered to be a fire hazard.
Explosion: Not considered to be an explosion hazard.
Fire Extinguishing Media: In case of fire, use carbon dioxide, water spray, dry chemical powder or appropriate foam.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. Water mist may be used to keep containers cool.
Special Hazards arising from the substance or mixture: Fumes, Carbon oxides, Nitrogen oxides (NOx), Calcium oxide.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Large Spill: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials.Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
9. Physical and Chemical Properties
Appearance: A white or almost white powder, slightly hygroscopic.
Odor: Odorless.
Odor threshold: Not applicable.
pH: 6 to 8
Relative density: No data found.
Melting Point: 195C literature.
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility(ies): No data found.
Viscosity: No data found.
10. Stability and Reactivity
Stability: Stable under ordinary storage conditions. Moisture sensitive. Heat sensitive.
Hazardous Decomposition Products: At higher temperatures, substance decomposes into Calcium oxide and Nitrogen oxides, Carbon dioxide and Carbon monoxide and fumes.
Hazardous Polymerization: This substance does not polymerize.
Incompatibilities: Oxidizing agents.
Conditions to Avoid: Oxidizing agents and heat.
11. Toxicological Information
Oral LD50 Rat: >10 gm/kg
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Mutagenic Effects: No data found.
Reproductive Effects: No data found.
Developmental Effects: No data found.
Teratogenicity: No data found.
12. Ecological Information
Environmental Toxicity: No data found.
Persistence and Degradability: No data found.
Mobility: No data found.
Results of PBT and vPvB assessment: No data found.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Follow all the pollution control rules.
14. Transport Information
DOT USA & ADR/RID Europe: Not controlled
IMDG: Not controlled
IATA: Not controlled.
15. Regulatory Information
USA:
California Proposition 65: Not listed.
SARA 311/312 Hazards: See section 2.
16. Other Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Calcium Pantothenate Structure
CAS Number 137-08-6, Calcium Pantothenate Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 22-nov-24
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