CAS Number 53716-49-7, Carprofen USP BP Ph Eur EP Grade Manufacturers Exporters
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CAS Number 53716-49-7, Carprofen USP BP Ph Eur EP Grade Manufacturer Exporter
For Properties Specifications of Carprofen Click Properties, Specifications of Carprofen Manufacturer.
For Uses of Carprofen Click Uses of Carprofen Manufacturer.
For For SDS MSDS Sheet of Carprofen Click SDS Safety Data Sheet MSDS Sheet of Carprofen Manufacturer.
The Properties and Specifications of Carprofen:
Carprofen USP Grade Specifications:
C15H12ClNO2 --- 273.71
9H -Carbazole-2-acetic acid, 6-chloro-α-methyl-, (±)-.
(±)-6-Chloro-α-methylcarbazole-2-acetic acid
CAS 53716-49-7
UNII: FFL0D546HO
Carprofen contains not less than 98.0 percent and not more than 102.0 percent of C15H12ClNO2 calculated on the dried basis.
Packaging and storage: Preserve in tight, light-resistant containers. Store at 25°, excursions permitted between 15° and 30°.
Labeling: Label it to indicate that it is intended for veterinary use only.
Identification:
A: Infrared Absorption.
B: The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation.
Loss on drying: Dry it at 105C for 2 hours: it loses not more than 0.5% of its weight.
Residue on ignition: not more than 0.1%.
Limit of acetone and methylene chloride: To pass the test. --- not more than 5000 ppm of acetone is found; and not more than 600 ppm of methylene chloride is found.
Related compounds: To pass the test.
Carprofen BP Ph Eur Grade Specifications:
C15H12ClNO2 --- 273.7 CAS 53716-49-7
Action and use: Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.
Preparations: Carprofen Injection, Carprofen Tablets.
DEFINITION
(2RS)-2-(6-Chloro-9H-carbazol-2-yl)propanoic acid.
Content: 98.5 per cent to 101.5 per cent (dried substance).
CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Practically insoluble in water, freely soluble in acetone, soluble in methanol, slightly soluble in 2-propanol.
IDENTIFICATION
Infrared absorption spectrophotometry.
TESTS
Appearance of solution: The solution is clear and not more intensely coloured than reference solution. Dissolve 1.0 g in methanol and dilute to 25 mL with the same solvent.
Related substances: To pass the test by Liquid chromatography.
Heavy metals: Maximum 20 ppm.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105C for 2 h.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Storage: Protected from light.
Carprofen EP Grade is also offered.
The Uses of Carprofen:
Carprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the carbazole and propionic acid class that was previously for use in humans and animals but is now only used by veterinarians for prescribing as a supportive treatment for various conditions in animals.
The MSDS-SDS Hazard Statement of Carprofen:
Carprofen SDS, Safety Data Sheet
MSDS
1. Product Identification
Product Name & Other Names: Carprofen.
CAS No.: 53716-49-7
EINECS Number: 258-712-4
Relevant uses and uses advised against (if any): Laboratory Chemicals and Industrial Use only.
Supplier: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute oral toxicity Category 3 H301
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements Toxic |
Signal Word: Danger
Hazard statements:
H301: Toxic if swallowed.
Precautionary statements:
P202: Do not handle until all safety precautions have been read and understood.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink, or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P330: Rinse mouth.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a comfortable position for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P405: Store locked up.
P501: Dispose of contents/container to authorized agents only.
3. Composition/Information on Ingredients
Product Name & Other Names: Carprofen.
CAS No.: 53716-49-7
EINECS Number: 258-712-4
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: If inhaled, remove to fresh air. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Give large amounts of water to drink. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Cold water may be used. Wash clothing & Shoes before reuse. Get medical attention.
Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush your eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention.
Notes to Physician: Treat symptomatically.
5. Fire Fighting Measures
Fire: Not combustible, however, it can burn at high temperature. Decomposes on heating emitting toxic fumes.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Use means suitable for extinguishing surrounding fire. Avoid heavy water stream. Cool containers with water spray until well after the fire is out. Avoid getting water inside containers.
Decomposition Products: Fumes, hydrogen chloride, chlorine along with nitrogen oxides.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved people should evacuate to a safe place.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Wear respiratory protection. Avoid breathing vapors, mist, or gas. Ensure adequate ventilation. Keep people away from upwind of spill/leak. Evacuate personnel to safe areas. Pick up and arrange disposal without creating dust. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allowing it to evacuate as per law.
7. Handling and Storage
Do not breathe vapor/dust/mist. Do not get in eyes, on skin, or on clothing. Avoid dust formation. Do not ingest.
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, acid, and bases. Storage: Room Temperature (Recommended in a cool and dark place, <15°C). Better to refrigerate.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: Not established.
Engineering Controls: Showers, Eyewash stations, Ventilation systems.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
9. Physical and Chemical Properties
Appearance: White or almost white, crystalline powder.
Odor: No data found.
Odor threshold: No data found.
pH: No data found.
Relative density: No data found.
Melting Point: 197C to 204C literature. (Other range is also reported).
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Practically insoluble in water. Freely soluble in acetone. Soluble in methanol.
Viscosity: No data found.
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage. Reacts with (some) acids: release of toxic and corrosive gases/vapors (hydrochloric acid).
Hazardous Decomposition Products: Fumes, hydrogen chloride along with nitrogen oxides may be released.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidants, acid, and bases.
Conditions to Avoid: Heat, Direct sunlight, Moisture, and Incompatibles. Always avoid Strong acids, Strong alkalis, Oxidizing agents.
11. Toxicological Information
Acute toxicity: Toxic if swallowed.
LD50 Oral, Rat - 74 mg/kg
Carcinogenicity: Not classifiable as to its carcinogenicity to humans by IARC, ACGIH, NTP, or EPA.
Reproductive toxicity: No data found.
Developmental Effects: No data found.
Teratogenicity: No data found.
12. Ecological Information
Toxicity to fish: No data found.
Persistence and Degradability: No data found.
Mobility: No data found.
Results of PBT and vPvB assessment: No data found.
13. Disposal Considerations
Whatever cannot be saved for recovery, or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of containers and unused contents in accordance with federal, state, and local requirements.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe:
UN number: 2811, Class: 6.1, Packing group: III.
Proper shipping name: Toxic solid, organic, n.o.s. (Carprofen).
IMDG/IMO & IATA/ICAO:
UN number: 2811, Class: 6.1, Packing group: III.
Proper shipping name: Toxic solid, organic, n.o.s. (Carprofen).
15. Regulatory Information
USA:
SARA 311/312 Hazard Categories: Chronic Health Hazard.
California Proposition 65: This product does not contain Proposition 65 chemicals.
Section 16 - Additional Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Anmol Chemicals Industries Pvt. Ltd. is an off-shoot of Anmol Chemicals and Anmol Chemicals & Pharmaceuticals, Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals Industries Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Carprofen Structure
CAS Number 53716-49-7, Carprofen Manufacturer Exporter
ANMOL CHEMICALS INDUSTRIES Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: 91-22-65290110
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 23-may-26
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