CAS Number 147098-20-2, Rosuvastatin Calcium EP BP Ph Eur IP USP Grade Manufacturers Exporters
------ 
CAS Number 147098-20-2, Rosuvastatin Calcium EP BP Ph Eur IP USP Manufacturer Exporter
For Properties Specifications of Rosuvastatin Calcium Click Properties, Specifications of Rosuvastatin Calcium Manufacturer.
For Uses of Rosuvastatin Calcium Click Uses of Rosuvastatin Calcium Manufacturer.
For For SDS MSDS Sheet of Rosuvastatin Calcium Click SDS Safety Data Sheet MSDS Sheet of Rosuvastatin Calcium Manufacturer.
The Properties and Specifications of Rosuvastatin Calcium:
Rosuvastatin Calcium BP Ph Eur Grade Specifications:
C44H54CaF2N6O12S2 --- 1001 --- CAS 147098-20-2
DEFINITION
Calcium bis[(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate].
Content: 97.0 per cent to 102.0 per cent (anhydrous substance).
CHARACTERS
Appearance: White or almost white, hygroscopic powder.
Solubility: Slightly soluble in water, freely soluble in methylene chloride, practically insoluble in anhydrous ethanol.
IDENTIFICATION
A. Infrared absorption spectrophotometry.
B. Enantiomeric purity.
C. It gives reaction of calcium.
TESTS
Related substances: To pass the test by Liquid chromatography.
Enantiomeric purity: To pass the test by Liquid chromatography.
Water: Maximum 6.1 per cent, determined on 0.100 g.
Rosuvastatin Calcium USP Grade Specifications:
Ca(CHFNOS) 1001.14 6-Heptenoic acid, 7-[4-(4-uorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, calcium salt(2:1), (3R,5S,6E); [S-[R*,S*-(E)]]-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid,calcium salt (2:1); Calcium (3R,5S,E)-7-(4-(4-uorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate salt (1:2)
CAS 147098-20-2.
DEFINITION
Rosuvastatin Calcium contains NLT 97.0% and NMT 103.0% of rosuvastatin calcium [Ca(CHFNOS)], calculated on the anhydrous and solvent-free basis.
IDENTIFICATION
A. Spectroscopic Identification Tests.
B. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the test for Enantiomeric Purity.
C. Identification Tests—General, Chemical Identification Tests, Calcium.
Organic Impurities: To pass the test by chromatography.
Enantiomeric Purity: To pass the test by chromatography.
Limit of Chloride: NMT 0.2%
Water Determination: NMT 6%.
Packaging and Storage: Preserve in well-closed containers, protected from light. Store at controlled room temperature.
We also manufacture Rosuvastatin Calcium or Rosuvastatin Hemicalcium or Rosuvastatin Calcium Salt IP EP Grade.
The Uses of Rosuvastatin Calcium:
Rosuvastatin is a medication used to treat high cholesterol and prevent heart attacks and strokes.
The MSDS-SDS Hazard Statement of Rosuvastatin Calcium:
Rosuvastatin Calcium or Rosuvastatin Hemicalcium or Rosuvastatin Calcium Salt SDS Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 16-Nov-24
1. Product Identification
Product Name & Other Names: Rosuvastatin Calcium or Rosuvastatin Hemicalcium or Rosuvastatin Calcium Salt.
CAS No.: 147098-20-2
EINECS EC Code: 627-028-1
Relevant uses and uses advised against (if any): Industrial Manufacturing.
SUPPLIER: AS per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements None |
Signal Words: None
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Product Name & Other Names: Rosuvastatin Calcium or Rosuvastatin Hemicalcium or Rosuvastatin Calcium Salt.
CAS No.: 147098-20-2
EINECS EC Code: 627-028-1
4. FIRST AID MEASURES
Always get medical attention after the first aid is over.
Emergency and First Aid Procedures:
Eyes - Flush with water for at least 15 minutes, raising and lowering eyelids occasionally. Get medical attention if irritation persists.
Skin - Thoroughly wash exposed area for at least 15 minutes. Remove contaminated clothing. Launder contaminated clothing before reuse. Get medical attention if irritation persists.
Ingestion - If swallowed, if conscious, give plenty of water. Immediately call a physician.
Inhalation - Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep a person warm, quiet, and get medical attention.
5. FIREFIGHTING PROCEDURES
Extinguisher Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Avoid solid water jet as it can spread fire.
Special Firefighting Procedures: Firefighters should wear full protective equipment and NIOSH approved self-contained breathing apparatus.
Unusual Fire and Explosion Hazards: Heated to decomposition, however, toxic oxides of sulfur, fluorine compounds, calcium compounds, oxides of nitrogen and oxides of carbon along with fumes may be evolved.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
6. SPILL OR LEAK PROCEDURES
Personal precautions, protective equipment, and emergency procedures: Ventilate area of spill. Avoid creating dust. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.
7. SPECIAL PRECAUTIONS
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Provide appropriate exhaust ventilation at places where dust is formed. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like Strong oxidizing agents. Storage: Freezer. Heat Sensitive.
8. SPECIAL PROTECTION INFORMATION
Exposure limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Respiratory Protection (Specify Type): None needed under normal conditions of use with adequate ventilation.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. PHYSICAL DATA
Physical State: White to almost white powder to crystal.
Odor: No data found.
Odor threshold: No data found.
pH: No data found.
Relative density: No data found.
Melting Point: 160C literature.
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility in Water: Sparingly soluble in water.
Viscosity: No data found.
10. REACTIVITY DATA
Stability: Stable.
Conditions to Avoid: Dust generation, Incompatibles
Incompatibility (Materials to Avoid): Strong oxidizing agents.
Hazardous Decomposition Products: Compounds of fluorine, calcium compounds, nitrogen, sulfur, and carbon oxides along with fumes.
Hazardous Polymerization: Will not occur.
11. TOXICITY DATA
Toxicity Data: No data found.
Carcinogenicity: Not listed as carcinogen by IARC, ACGIH, OSHA and NTP.
Mutagenic Effects: No data found.
Developmental Toxicity: No data found.
Reproductive Effects: No data found.
12. ECOLOGICAL DATA
Toxicity to fish, daphnia, and other aquatic invertebrates: No data available.
Persistence and Degradability: No data found.
Mobility: No data found.
Results of PBT and vPvB assessment: No data found for assessment.
13. DISPOSAL INFORMATION
Waste Disposal Methods: Dispose in accordance with all applicable regulations.
14. TRANSPORT INFORMATION
DOT (USA) & ADT/RID Europe: Not controlled.
IMDG & IATA: Not controlled.
15. REGULATORY INFORMATION
USA Regulations:
SARA 311/312 Hazard Categories: See section 2.
16. ADDITIONAL INFORMATION
Disclaimer:
****************************
The information and recommendations set forth herein are presented in good faith and believed correct as of the date the SDS was created. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This SDS is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. This shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship.
****************************
Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Rosuvastatin Calcium Structure
CAS Number 147098-20-2, Rosuvastatin Calcium Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 24-nov-24
We manufacture: