CAS Number 26921-17-5, Timolol Maleate IP EP BP Ph Eur USP JP Grade Manufacturers Exporters
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CAS Number 26921-17-5, Timolol Maleate IP EP BP Ph Eur USP JP Manufacturer Exporter
For Properties Specifications of Timolol Maleate Click Properties, Specifications of Timolol Maleate Manufacturer.
For Uses of Timolol Maleate Click Uses of Timolol Maleate Manufacturer.
For For SDS MSDS Sheet of Timolol Maleate Click SDS Safety Data Sheet MSDS Sheet of Timolol Maleate Manufacturer.
The Properties and Specifications of Timolol Maleate:
Timolol Maleate BP Ph Eur Grade:
C17H28N4O7S --- 432.5 CAS 26921-17-5
DEFINITION
(2S)-1-[(1,1-Dimethylethyl)amino]-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol (Z)-butenedioate.
Content: 98.5 per cent to 101.0 per cent (dried substance).
CHARACTERS
Appearance: White or almost white, crystalline powder or colourless crystals.
Solubility: Soluble in water and in ethanol (96 per cent).
mp: about 199C, with decomposition.
IDENTIFICATION
First identification: A, B
Second identification: A, C, D
A. Specific optical rotation: -6.2 to -5.7.
Dissolve 1.000 g in 1 M hydrochloric acid and dilute to 10.0 mL with the same acid.
B. Infrared absorption spectrophotometry.
C. Thin-layer chromatography.
D. To pass the test.
Appearance of solution: Solution S is clear and not more intensely coloured than reference solution.
pH: 3.8 to 4.3 for solution S.
Enantiomeric purity: To pass the test. --- 1.0 per cent.
Related substances: To pass the test.
Loss on drying: Maximum 0.5 per cent, determined on 1.000& g by drying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Storage: Protected from light.
Timolol Maleate USP Grade Specifications:
C13H24N4O3S-C4H4O4 --- 432.49
2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (S)-, (Z)-2-butenedioate (1:1) (salt);
(−)-1-(tert-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate (1:1) (salt) CAS 26921-17-5
UNII: P8Y54F701R
UNII: 5JKY92S7BR
DEFINITION
Timolol Maleate contains NLT 98.0% and NMT 102.0% of timolol maleate (C13H24N4O3S-C4H4O4), calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption
B. Ultraviolet Absorption
C. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
Residue on Ignition: NMT 0.1%
Organic Impurities: To pass the test.
Optical Rotation, Specific Rotation:
Sample solution: 50 mg/mL of Timolol Maleate in 1.0 N hydrochloric acid.
Acceptance criteria: −11.7° to −12.5° (λ = 405 nm)
pH: For 20 mg/mL of Timolol Maleate in water. Acceptance criteria: 3.8 to 4.3
Loss on Drying: Dry under vacuum at 100C to constant weight. Acceptance criteria: NMT 0.5%
We also manufacture Timolol Maleate JP EP Grade.
The Uses of Timolol Maleate:
Timolol is a beta blocker medication used either by mouth or as eye drops. Timolol Maleate is used to treat high pressure inside the eye due to glaucoma (open angle-type) or other eye diseases. Lowering high pressure inside the eye helps to prevent blindness.
The MSDS-SDS Hazard Statement of Timolol Maleate:
Timolol Maleate SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 16-Nov-24
1. Product Identification
Product Name & Other Names: Timolol Maleate.
CAS Number: 26921-17-5 or 60469-65-0
EINECS EC Number: 248-111-5
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral Category 4, H302
Reproductive toxicity Category 2, H361
Labeling according to GHS USA & Regulation (EC) No 1272/2008
GHS Label Elements  Harmful |
GHS Label Elements |
Signal Words: Warning
Hazard Statements:
H302: Harmful if swallowed.
H361: Suspected of damaging fertility or the unborn child.
Precautionary Statements:
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310: IF SWALLOWED: Immediately call a POSION CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P308+P313: IF exposed or concerned: Get medical advice/ attention.
3. Composition/Information on Ingredients
Product Name & Other Names: Timolol Maleate.
CAS Number: 26921-17-5 or 60469-65-0
EINECS EC Number: 248-111-5
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove affected person to fresh air; if normal breathing has not returned within a few minutes after exposure, get medical attention.
Skin: Remove contaminated clothing; wash affected area with soap and water; launder contaminated clothing before reuse. Seek medical attention.
Eyes: Immediately, flush eyes for 15 minutes in clear running water while holding eyelids open; seek medical attention immediately.
Ingestion: Drink two glasses of water followed by milk, milk of magnesia or other non-alcoholic liquids; Do not induce vomiting; seek medical attention immediately.
Physician may treat symptomatically.
5. Fire Fighting Measures
General Hazards: Product will support combustion.
Extinguishing Media: Carbon dioxide, water fog, dry chemical, chemical foam. Keep containers cool by spraying with water. Use extinguishing media appropriate for surrounding fire. Avoid solid water jet as it can scatter the fire.
Fire & Explosion Hazard: May evolve oxides of carbon (COx), nitrogen oxides, sulfur oxides and fumes under fire conditions.
In case of fire, wear a full face positive-pressure self-contained breathing apparatus and protective suit. Self - contained respiratory equipment; cool containers to prevent pressure buildup and explosion when exposed to extreme heat.
Unusual Fire and Explosion Hazards: Closed containers can explode due to buildup of pressure when exposed to extreme heat.
Hazardous Combustion Products: Products of combustion include nitrogen oxides, sulfur oxides, CO, CO2 and toxic fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter sewer, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Vacuum or sweep up and remove to an approved disposal container.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Keep containers closed when not in use; protect containers from abuse; protect from extreme temperatures, open flames. Room temperature.
8. Exposure Controls/Personal Protection
Engineering Controls: The use of local exhaust ventilation is recommended to control emissions near the source. Provide mechanical ventilation of confined spaces.
Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: A white or almost white crystals or powder.
Odor: No data found.
Odor threshold: No data found.
pH: 3.8 to 4.3 in 2% solution.
Relative density: No data found.
Melting point/freezing point: 198C literature.
Boiling Point: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor Pressure (MM Hg): No data found.
Vapor Density (Air = 1): No data found.
Evaporation Rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility in Water: Soluble in water and methanol, ethanol (96%). Sparingly soluble in chloroform.
Viscosity: No data found.
10. Stability and Reactivity
Stability: Stable at recommended temperatures and operating conditions.
Conditions to Avoid: Avoid excessively high temperatures, sunlight, air, and incompatibles.
Incompatibilities: Strong oxidizing agents.
Decomposition: Decomposition yields nitrogen oxides, sulfur oxides, carbon monoxide & dioxide, fumes.
Polymerization: Polymerization will not occur.
11. Toxicological Information
Reproduction: Suspected of damaging the unborn child. Suspected of damaging fertility.
Mutagenicity: No data found.
Carcinogenicity: Not listed as a human carcinogen by OSHA, IARC, ACGIH & NTP.
Acute Oral Effects: Oral LD50 Rats: 1028 mg/kg.
Acute Dermal Toxicity: LD50 Dermal Rat: 3129 mg/kg.
12. Ecological Information
Toxicity to fresh-water fish: No data found.
Persistence and accumulation: No data found.
Mobility: No data found.
13. Disposal Considerations
Dispose in accordance with Local, State, and Federal Regulations. Consult local, state, or Federal Environmental Protection Agency before disposing of any chemicals. Follow all the pollution control laws.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
IMDG/IMO & IATA/ICAO: Not dangerous goods.
15. Regulatory Information
UNITED STATES REGULATORY INFORMATION
SARA 311/312 Hazard Categories: See section 2.
Section 16 - Additional Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Timolol Maleate Structure
CAS Number 26921-17-5, Timolol Maleate Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 16-nov-24
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