CAS Number 1492-18-8, Calcium Folinate Hydrate BP Ph Eur Grade Manufacturers Exporters
------ 
CAS Number 1492-18-8, Calcium Folinate Hydrate BP Ph Eur Manufacturer Exporter
For Properties Specifications of Calcium Folinate Hydrate Click Properties, Specifications of Calcium Folinate Hydrate Manufacturer.
For Uses of Calcium Folinate Hydrate Click Uses of Calcium Folinate Hydrate Manufacturer.
For For SDS MSDS Sheet of Calcium Folinate Hydrate Click SDS Safety Data Sheet MSDS Sheet of Calcium Folinate Hydrate Manufacturer.
The Properties and Specifications of Calcium Folinate Hydrate:
Calcium Folinate BP Ph Eur Grade Specifications
Ph Eur
C20H21CaN7O7-xH2O --- 511.5 --- 1492-18-8
Action and use: Antidote to folic acid antagonists.
DEFINITION
Calcium (2S)-2-[[4-[[[(6RS)-2-amino-5-formyl-4-oxo1,4,5,6,7,8-hexahydropteridin-6-yl]methyl]amino]benzoyl]amino]pentanedioate.
Content:
calcium folinate (C20H21CaN7O7): 97.0 per cent to 102.0 per cent (anhydrous substance);
calcium (Ca; A r 40.08): 7.54 per cent to 8.14 per cent (anhydrous substance). It contains a variable amount of water.
CHARACTERS
Appearance: White or light yellow, amorphous or crystalline powder.
Solubility: Sparingly soluble in water, practically insoluble in acetone and in ethanol (96 per cent). The amorphous form may produce supersaturated solutions in water.
IDENTIFICATION
First identification A, B, D.
Second identification A, C, D.
A. Specific optical rotation.
B. Infrared absorption spectrophotometry.
C. Thin-layer chromatography.
D. It gives reaction of calcium.
Carry out the tests and the assay as rapidly as possible, protected from actinic light.
TESTS
Solution S: Dissolve 1.25 g in carbon dioxide-free water, heating at 40C if necessary, and dilute to 50.0 ml with the same solvent.
Appearance of solution: Solution S is clear and its absorbance at 420 nm is not greater than 0.60.
pH: 6.8 to 8.0 for solution S.
Specific optical rotation: + 14.4 to + 18.0 (anhydrous substance), determined on solution S.
Acetone, ethanol and methanol Limits:
acetone: maximum 0.5 per cent;
ethanol: maximum 3.0 per cent;
methanol: maximum 0.5 per cent.
Related substances: To pass the test,
Chlorides: Maximum 0.5 per cent.
Heavy metals: Maximum 50 ppm.
Platinum: Maximum 20.0 ppm.
Water: Maximum 17.0 per cent, determined on 0.200 g (ground to a very fine powder ).
Bacterial endotoxins: Less than 0.5 IU/mg, if intended for use in the manufacture of parenteral dosage forms without a further appropriate procedure for the removal of bacterial endotoxins.
The Uses of Calcium Folinate Hydrate:
Calcium folinate is used as to reduce the harmful effects of folate antagonists such as methotrexate.
The MSDS-SDS Hazard Statement of Calcium Folinate Hydrate:
Calcium Folinate SDS, SAFETY DATA SHEET
MSDS Sheet, MATERIAL SAFETY DATA SHEET 04-Nov-24
1. PRODUCT IDENTIFICATION
Product Name & Other Names: Calcium Folinate
CAS Number: 1492-18-8 (anhydrous)
Relevant uses and uses advised against (if any): Laboratory and Industrial Manufacturing.
SUPPLIER: As per letterhead.
2. HAZARDS IDENTIFICATION
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Skin corrosion/irritation Category 2, H315
Sensitization, Skin Category 1, H317
Serious eye damage/eye irritation Category 2A, H319
Sensitization, respiratory Category 1, H334
Specific target organ toxicity, single exposure; Respiratory tract irritation Category 3, H335
Labeling according Regulation (EC) No 1272/2008
GHS Label Elements  Irritant |
GHS Label Elements |
Signal Words: Danger
Hazard Statements:
H315: Causes skin irritation.
H317: May cause an allergic skin reaction.
H319: Causes serious eye irritation.
H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335: May cause respiratory irritation.
Precautionary Statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P264: Wash --- thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+352: IF ON SKIN: Wash with soap and water.
P332+313: If skin irritation occurs: Get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P333+313: If skin irritation or a rash occurs: Get medical advice/attention.
P337+313: If eye irritation persists get medical advice/attention.
3. COMPOSITION / INFORMATION ON INGREDIENTS
Product Name & Other Names: Calcium Folinate
CAS Number: 1492-18-8 (anhydrous)
4. FIRST-AID MEASURES
Always seek medical attention after first aid measures are provided.
Eye Contact: Rinse immediately with plenty of water for 10 minutes at least. Contact a physician if symptoms persist.
Skin Contact: Wash thoroughly with soap and water; flush with plenty of water. Take off spoilt clothes. Contact physician if symptoms persist.
Ingestion: Wash the mouth with water; seek medical advice immediately.
Inhalation: Remove from exposure site to fresh air and keep at rest. Obtain medical advice.
5. FIRE-FIGHTING MEASURES
Extinguishing Media Recommended: Water spray, CO2, foam, dry chemicals. Use an extinguishing agent suitable for the surrounding fire.
Non-Recommended: Do not use direct water jet on burning material.
Extinguishing Procedure: Closed containers may build up pressure at elevated temperatures. If possible, containers should be cooled with a water spray.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.
6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.
7. HANDLING AND STORAGE
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, strong acids, alkali.
8. EXPOSURE CONTROL
Respiratory Protection: Avoid to breath directly on the product. Apply local ventilations when appropriate.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Light yellow crystalline powder
Odor: Odorless.
Odor threshold: Not applicable.
pH: 6.8 - 8.0 at 25 g/l
Relative density: around 1.01
Melting point/freezing point: No data found.
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition Temperature: 240C - 250C
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Soluble in water.
Viscosity: No data found.
10. STABILITY AND REACTIVITY
Reactivity: It presents no significant reactivity hazards. Avoid contact with strong acids, alkali, or oxidizing agents.
Decomposition: Carbon monoxide Carbon oxides, Nitrogen oxides (NOx), Calcium oxide and toxic unidentified organic compounds may be formed during combustion.
11. TOXICOLOGICAL INFORMATION
LD 50 ORAL/RAT (mg/Kg): 8000
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Teratogenic Effects: No data found.
Mutagenic Effects: No data found.
Developmental Toxicity: No data found.
Reproductive Effects: No data found.
12. ECOLOGICAL INFORMATION
Toxicity to fish: No data available
Results of PBT and vPvB assessment: This substance/mixture is not considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Precautions: Prevent contamination of soil, ground and surface water.
13. DISPOSAL CONSIDERATIONS
In accordance with local environmental laws. Avoid disposing into drainage systems and into the environment. Follow all the waste disposal rules.
14. TRANSPORT REGULATIONS
DOT USA: Not regulated.
ADR/RID Europe: Not regulated.
IMDG: Not regulated.
IATA: Not regulated.
15. REGULATORY INFORMATION
USA:
SARA 311/312 Hazards: See section 2.
California Prop 65 Components: No listed to cause cancer, birth defects, or any other reproductive harm.
16 - ADDITIONAL INFORMATION
Disclaimer:
**************************
Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
**************************
Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Calcium Folinate Hydrate Structure
CAS Number 1492-18-8, Calcium Folinate Hydrate Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 16-nov-24
We manufacture:
Aluminum Chloride Hexahydrate Anhydrous