CAS Number 86386-73-4, Fluconazole USP IP BP Ph Eur EP JP Grade Manufacturers Exporters
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CAS Number 86386-73-4, Fluconazole USP IP BP Ph Eur EP JP Grade Manufacturer Exporter
For Properties Specifications of Fluconazole Click Properties, Specifications of Fluconazole Manufacturer.
For Uses of Fluconazole Click Uses of Fluconazole Manufacturer.
For For SDS MSDS Sheet of Fluconazole Click SDS Safety Data Sheet MSDS Sheet of Fluconazole Manufacturer.
The Properties and Specifications of Fluconazole:
Fluconazole USP Grade Specifications:
C13H12F2N6O --- 306.27
1H -1,2,4-Triazole-1-ethanol, 1-(2,4-difluorophenyl)-1-(1H -1,2,4-triazol-1-ylmethyl)-;
2,4-Difluoro-1′,1′-bis(1H -1,2,4-triazol-1-ylmethyl)benzyl alcohol CAS 86386-73-4
UNII: 8VZV102JFY
DEFINITION
Fluconazole contains NLT 98.0% and NMT 102.0% of C13H12F2N6O, calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption.
B. Ultraviolet Absorption.
Organic Impurities, Procedure 1: To pass the test by chromatography.
Organic Impurities, Procedure 2: To pass the test by chromatography.
Organic Impurities, Procedure 3: To pass the test by thin layer chromatography.
Residue on Ignition: NMT 0.1%
Iron: Acceptance criteria: NMT 20 ppm.
Loss on Drying: Dry a sample at 105C for 3 h: it loses NMT 0.5% of its weight.
Clarity and Color of Solution: Dissolve a sample in methanol to obtain a 5-in-100 solution (w/v). Acceptance criteria: The solution is clear and colorless.
Packaging and Storage: Preserve in tight containers, and store below 30C.
Fluconazole BP Ph Eur Grade Specifications:
C13H12F2N6O --- 306.3 CAS 86386-73-4
Action and use: Antifungal.
DEFINITION
2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol.
Content: 99.0 per cent to 101.0 per cent (dried substance).
CHARACTERS
Appearance: White or almost white, hygroscopic, crystalline powder.
Solubility: Slightly soluble in water, freely soluble in methanol, soluble in acetone.
It shows polymorphism.
IDENTIFICATION
Infrared absorption spectrophotometry.
TESTS
Appearance of solution: The solution is clear and colourless.
Dissolve 1.0 g in methanol and dilute to 20 mL with the same solvent.
Related substances: To pass the test by Liquid chromatography.
Storage: In an airtight container.
We also manufacture Fluconazole EP IP JP grade.
The Uses of Fluconazole:
Fluconazole is an antifungal medication used for a number of fungal infections.The MSDS-SDS Hazard Statement of Fluconazole:
Fluconazole SDS, Safety Data Sheet MSDS Sheet, Material safety Data Sheet 03-Nov-24
1. Product Identification
Product Name & Other Names: Fluconazole.
CAS No.: 86386-73-4
EINECS: EC Number: 627-806-0
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), (H302)
Skin irritation (Category 2), (H315)
Eye irritation (Category 2), (H319)
Specific target organ toxicity - single exposure Category 3, (H335)
Reproductive toxicity Category 1B, (H360)
Labeling according to Regulation (EC) No 1272/2008
GHS Label Elements  Health Hazard |
GHS Label Elements |
Signal word: Danger.
Hazard statements:
H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
H360: May damage fertility. May damage the unborn child.
Precautionary statements:
P210: Keep away from heat/sparks/open flames/hot surfaces – No smoking.
P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink, or smoke when using this product.
P280 Wear protective gloves/ eye protection/ face protection.
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308+313: IF exposed or concerned: Get medical advice/attention.
P501: Dispose of contents/container to an authorized agent only.
3. Composition/Information on Ingredients
Product Name & Other Names: Fluconazole.
CAS No.: 86386-73-4
EINECS: EC Number: 627-806-0
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
Note to Physician: Symptomatic and supportive treatment is recommended.
5. Fire Fighting Measures
Flammability of the Product: It is an organic combustible material.
Products of Combustion: It emits Carbon oxides, Nitrogen oxides, Fluorine compounds and fumes when heated to decomposition.
Fire Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Avoid solid water jet.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Eliminate all sources of ignition. Avoid dust-mist formation. Avoid breathing dust. Ensure adequate ventilation. Use appropriate tools to put the spilled material in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and disposing of it according to local and regional authority requirements. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.
Large Spill: Eliminate all sources of ignition. Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Room Temperature. Recommended in a cool and dark place, <15C. Hygroscopic.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: No adequate information found. Better keep it below 10 ppm.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: White to almost white powder or crystals.
Odor: No data found.
Odor threshold: No data found.
pH: No data found.
Relative density: No data found.
Boiling Point: 580C predicted.
Melting Point: 138C-140C literature.
Flash Point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Slightly soluble in water. Soluble in methanol.
Viscosity: No data found.
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage. Hygroscopic,
Hazardous Decomposition Products: It emits Carbon oxides, Nitrogen oxides, Fluorine compounds and fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents and Heat.
Conditions to Avoid: Moisture, Heat, Incompatibles.
11. Toxicological Information
Toxicity to Animals:
ORAL (LD50): 1271 mg/kg (Rat).
Carcinogenic Effects: Not a reported carcinogen.
Mutagenic Effects: No data found.
Teratogenic Effects: No data found.
Developmental Toxicity: May damage fertility. May damage the unborn child.
12. Ecological Information
BOD5 and COD: Not available.
Environmental Toxicity: Not available.
Results of PBT and vPvB assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
IMDG/IMO: Not dangerous goods.
IATA: Not dangerous goods.
15. Regulatory Information
USA:
SARA 311/312 Hazards: See section 2.
16. Other Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Fluconazole Structure
CAS Number 86386-73-4, Fluconazole Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 18-nov-24
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