CAS Number 132539-06-1, Olanzapine EP BP Ph Eur IP USP Grade Manufacturers Exporters
------ 
CAS Number 132539-06-1, Olanzapine EP BP Ph Eur IP USP Manufacturer Exporter
For Properties Specifications of Olanzapine Click Properties, Specifications of Olanzapine Manufacturer.
For Uses of Olanzapine Click Uses of Olanzapine Manufacturer.
For For SDS MSDS Sheet of Olanzapine Click SDS Safety Data Sheet MSDS Sheet of Olanzapine Manufacturer.
The Properties and Specifications of Olanzapine:
Olanzapine BP Ph Eur Grade:
C17H20N4S --- 312.4 CAS 132539-06-1
Action and use: Dopamine D2 receptor antagonist; serotonin 5HT2 receptor antagonist; neuroleptic.
DEFINITION
2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine.
Content: 98.0 per cent to 102.0 per cent (anhydrous substance).
CHARACTERS
Appearance: Yellow, crystalline powder.
Solubility: Practically insoluble in water, freely soluble in methylene chloride, slightly soluble in ethanol (96 per cent). It shows polymorphism.
IDENTIFICATION
Infrared absorption spectrophotometry.
TESTS
Related substances: To pass the test by Liquid chromatography.
Olanzapine USP Grade Specifications:
C17H20N4S --- 312.43
10H -Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-;
2-Methyl-4-(4-methyl-1-piperazinyl)-10H -thieno[2,3-b][1,5] benzodiazepine
CAS: 132539-06-1
UNII: N7U69T4SZR
DEFINITION
Olanzapine contains NLT 98.0% and NMT 102.0% of olanzapine (C17H20N4S), calculated on the anhydrous, solvent-free basis.
IDENTIFICATION
A. Infrared Absorption.
B. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
Residue on Ignition: NMT 0.1%
Organic Impurities: To pass the test by chromatography.
Water Determination: NMT 1.0%
We also manufacture Olanzapine EP IP Grade.
The Uses of Olanzapine:
Olanzapine is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder.
The MSDS-SDS Hazard Statement of Olanzapine:
Olanzapine SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 15-Nov-24
1. Product Identification
Product Name & Other Names: Olanzapine.
CAS No.: 132539-06-1
EINECS EC Code: 603-618-4
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 3) H301
Skin corrosion (Category 1B) H315
Skin sensitization (Category 1) H317
Eye irritation (Category 2) H319
Labeling according to GHS USA & Regulation (EC) No 1272/2008
GHS Label Elements  Toxic |
GHS Label Elements |
Signal Word: Danger
Hazard Statements:
H301: Toxic if swallowed
H315: Causes skin irritation.
H317: May cause an allergic skin reaction
H319: Causes serious eye irritation.
Precautionary Statements
P202: Do not handle until all safety precautions have been read and understood.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280-Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P301+P310+330: IF SWALLOWED: Rinse mouth and immediately call a POISON CENTER or doctor/physician.
P302+P352: IF ON SKIN: Wash with soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P304+P341+P311: IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P314: Get Medical advice/attention if you feel unwell.
P337+P313: If eye irritation persists: Get medical advice/ attention.
3. Composition/Information on Ingredients
Product Name & Other Names: Olanzapine.
CAS No.: 132539-06-1
EINECS EC Code: 603-618-4
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove the victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Toxic if swallowed. Contact the medical center quickly. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: On contact, it can cause itching, pain, swelling and redness. Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse.
Eye Contact: It can cause severe irritation and harm to eyes. Check for and remove any contact lenses. Immediately flush your eyes with running water for at least 15 minutes, keeping eyelids open. Get medical attention.
5. Fire Fighting Measures
Fire: Toxic fumes, sulfur oxides, nitrogen oxide, carbon dioxide and carbon monoxide may be formed in fire.
Explosion: No data available
Fire Extinguishing Media: Dry chemical, foam or carbon dioxide and water spray jet. Avoid solid water jet as it can scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Sweep and shovel and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.
Large Spill: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.
7. Handling and Storage
Precautions for safe handling: Toxic. Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Keep away from heat and source of fire. Keep in tightly closed container. Storage: Freeze -20C. Heat Sensitive.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: Not established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to the substance is apparent and engineering controls are not feasible, consult an industrial hygienist.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: Yellow crystalline solid.
Odor: No data found.
Odor threshold: No data found.
pH: No data found.
Relative density: No data found.
Melting Point: 185C to 195C literature.
Initial boiling point and boiling range: 476C literature.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Practically insoluble in water.
Viscosity: No data found.
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Toxic fumes, sulfur oxides, nitrogen oxide, carbon dioxide and carbon monoxide may be formed in fire.
Hazardous Polymerization: Not reported.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Heat, flames, moisture, light, ignition sources and incompatibles.
11. Toxicological Information
Oral rat LD50: LD50 Oral Rat: 177 mg/kg.
Dermal rabbit: LD50 Dermal - Rabbit - > 200 mg/kg
Carcinogenicity: Not reported as carcinogen by any agency. No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed human carcinogen by IARC.
Reproductive Toxicity: No data found.
Developmental Effects: No data found.
Teratogenicity: No data found.
12. Ecological Information
Persistence and Degradability: No data found.
Bioaccumulation/ Accumulation: No data found.
Mobility: No data found.
Results of PBT and vPvB assessment: No data found.
Environmental Toxicity: No data found.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Follow all the pollution control laws.
14. Transport Information
DOT USA & ADR/RID Europe
UN Number: UN 2811
Proper shipping name: TOXIC SOLID, ORGANIC, N.O.S. (OLANZAPINE)
Class: 6.1, Packing group: III.
IMDG & IATA
UN Number: UN 2811
Proper shipping name: TOXIC SOLID, ORGANIC, N.O.S. (OLANZAPINE)
Class: 6.1, Packing group: III.
15. Regulatory Information
USA:
SARA 311/312: See section 2.
California Prop 65: Not listed.
Section 16 - Additional Information
DISCLAIMER: The information and recommendations set forth are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.
Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Olanzapine Structure
CAS Number 132539-06-1, Olanzapine Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 19-nov-24
We manufacture: