CAS Number 9005-65-6, Polysorbate 80 or Tween 80 USP NF BP Ph Eur FCC Food Grade Manufacturers Exporters
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CAS Number 9005-65-6, Polysorbate 80 or Tween 80 Manufacturer Exporter
For Properties Specifications of Polysorbate 80 or Tween 80 Click Properties, Specifications of Polysorbate 80 or Tween 80 Manufacturer.
For Uses of Polysorbate 80 Click Uses of Polysorbate 80 Manufacturer.
For For SDS MSDS Sheet of Polysorbate 80 Click SDS Safety Data Sheet MSDS Sheet of Polysorbate 80 Manufacturer.
The Properties and Specifications of Polysorbate 80:
Polysorbate 80 USP NF Grade Specifications
Sorbitan, mono-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs., (Z)-.
Polyoxyethylene 20 sorbitan monooleate CAS 9005-65-6
Polysorbate 80 is an oleate ester of sorbitol and its anhydrides copolymerized with approximately 20 moles of ethylene oxide for each mole of sorbitol and sorbitol anhydrides.
Identification:
A: To 5 mL of a solution (1 in 20) add 5 mL of sodium hydroxide. Boil for a few minutes, cool, and acidify with 3 N hydrochloric acid: the solution is strongly opalescent.
B: To 2 mL of a solution (1 in 20) add 0.5 mL of bromine dropwise: the bromine is decolorized.
C: A mixture of 60 volumes of it and 40 volumes of water yields a gelatinous mass at normal and lower than normal room temperatures.
Specific gravity: between 1.06 and 1.09.
Viscosity: between 300 and 500 centistokes when determined at 25C.
Acid value: Weigh 10.0 g into a wide-mouth, 250-mL conical flask, and add 50 mL of neutralized alcohol. Heat on a steam bath nearly to boiling, shaking thoroughly occasionally while heating. Invert a beaker over the mouth of the flask, cool under running water, add 5 drops of phenolphthalein and titrate with 0.1 N sodium hydroxide: not more than 4 mL of 0.100 N sodium hydroxide is required, corresponding to an acid value of 2.2.
Hydroxyl value: between 65 and 80.
Saponification value: between 45 and 55.
Water: not more than 3.0%.
Residue on ignition: not more than 0.25%.
Heavy metals: 0.001%.
Polysorbate 80 BP Ph Eur Grade Specifications
Polyoxyethylene 20 Sorbitan Mono-oleate
Action and use: Non-ionic surfactants.
DEFINITION
Mixture of partial esters of fatty acids, mainly Oleic acid (0799), with sorbitol and its anhydrides ethoxylated with approximately 20 moles of ethylene oxide for each mole of sorbitol and sorbitol anhydrides.
CHARACTERS
Appearance: Oily, yellowish or brownish-yellow, clear or slightly opalescent liquid.
Solubility: Dispersible in water, in anhydrous ethanol, in ethyl acetate and in methanol, practically insoluble in fatty oils and in liquid paraffin.
Relative density: About 1.10.
Viscosity: About 400 mPas at 25C.
IDENTIFICATION
First identification A, D.
Second identification B, C, D, E.
A. Infrared absorption spectrophotometry.
B. Hydroxyl value (see Tests).
C. Saponification value (see Tests).
D. Composition of fatty acids.
E. Dissolve 0.1 g in 5 ml of methylene chloride R. Add 0.1 g of potassium thiocyanate R and 0.1 g of cobalt nitrate R. Stir with a glass rod. The solution becomes blue.
TESTS
Acid value: Maximum 2.0.
Hydroxyl value: 65 to 80.
Peroxide value: Maximum 10.0.
Saponification value: 45 to 55, determined on 4.0 g.
Composition of fatty acids: To pass the test.
Ethylene oxide and dioxan: Maximum 1 ppm of ethylene oxide and maximum 10 ppm of dioxan.
Heavy metals: Maximum 10 ppm.
Water: Maximum 3.0 per cent, determined on 1.00 g.
Total ash: Maximum 0.25 per cent, determined on 2.0 g.
Polysorbate 80 FCC Food Grade Specifications
Polyoxyethylene (20) Sorbitan Monooleate; Sorbitan Mono-
9-octadecenoate; Poly(oxy-1,2-ethanediyl) Derivative
INS: 433 CAS 9005-65-6]
DESCRIPTION
Polysorbate 80 occurs as a yellow to orange colored, oily liquid. It is a mixture of oleate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 moles of ethylene oxide (C2H4O) for each mole of sorbitol and its mono- and dianhydrides. It is very soluble in water, producing a nearly colorless solution, and it is soluble in alcohol, in fixed oils, in ethyl acetate, and in toluene. It is insoluble in mineral oil.
Function: Emulsifier; stabilizer.
REQUIREMENTS
Identification:
A. Add 5 mL of 1 N sodium hydroxide to 5 mL of a 1:20 aqueous solution, boil for a few minutes, cool, and acidify with 2.7 N hydrochloric acid. The solution is strongly opalescent.
B. Add bromine dropwise, to a 1:20 aqueous solution. The bromine is decolorized.
C. A 60:40 (v/v) mixture of Polysorbate 80:water at 25C or below yields a gelatinous mass.
Assay for Oxyethylene Content: Not less than 65.0% and not more than 69.5% of oxyethylene groups C2H4O), equivalent to between 96.5% and 103.5% of Polysorbate 80, calculated on the anhydrous basis.
Acid Value: Not more than 2.
1,4-Dioxane: Not more than 10 mg/kg.
Hydroxyl Value: Between 65 and 80.
Lead: Not more than 2 mg/kg.
Oleic Acid: Between 22 and 24 g per 100 g of sample.
Residue on Ignition: Not more than 0.25%.
Saponification Value: Between 45 and 55.
Water: Not more than 3.0%.
The Uses of Polysorbate 80:
Polysorbate 80, also known as Tween 80, is a synthetic nonionic surfactant commonly used in food, cosmetics, and drug formulations as a solubilizer, stabilizer, or emulsifier. It is utilized as a surfactant in soaps and cosmetics and also as a lubricant in eye drops. In food or pharmaceutical products, it can act as an emulsifier. It functions as an emulsifier, a dispersant, a wetting agent, a solubilizer, and a stabilizer in food, pharmaceutical, cosmetics, pigments, textiles, etc. Polysorbate 80 is a common ingredient in hair care products.
The MSDS-SDS Hazard Statement of Polysorbate 80:
Polysorbate 80 SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 20-Jan-23
1. PRODUCT DESCRIPTION
Product Name & Other Names: Polysorbate 80; Polyoxymethylene 20 Sorbitan Mono-oleate.
CAS Number: 9005-65-6
EINECS EC Number: 500-019-9
Molecular Weight: 2917
Molecular Formula: C64H124O26
Relevant uses and uses advised against (if any): Industrial Manufacturing.
2. HAZARD IDENTIFICATION
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements None |
Signal Words: None
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Product Name & Other Names: Polysorbate 80; Polyoxymethylene 20 Sorbitan Mono-oleate.
CAS Number: 9005-65-6
EINECS EC Number: 500-019-9
4. FIRST AID MEASURES
Always get medical attention after the first aid is over.
Emergency and First Aid Procedures:
Eyes - Flush with water for at least 15 minutes, raising and lowering eyelids occasionally. Get medical attention if irritation persists.
Skin - Thoroughly wash exposed area for at least 15 minutes. Remove contaminated clothing. Launder contaminated clothing before reuse. Get medical attention if irritation persists.
Ingestion - If swallowed, if conscious, give plenty of water. Immediately call a physician. Never give anything by mouth to an unconscious person.
Inhalation - Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Get medical attention.
5. FIREFIGHTING PROCEDURES
Extinguisher Media: Water spray. Carbon dioxide (CO 2). Dry chemical. alcohol-resistant foam.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used.
6. SPILL OR LEAK PROCEDURES
Personal precautions, protective equipment and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Ensure adequate ventilation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Do not approach facing the wind.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Vacuuming or wet sweeping may be used to avoid dust dispersal and then remove to an approved disposal container.
7. SPECIAL PRECAUTIONS
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat or smoke while handling. Avoid contact with skin, eyes and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cold, dry and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing and bases.
8. SPECIAL PROTECTION INFORMATION
Exposure Guidelines: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Respiratory Protection (Specify Type): None needed under normal conditions of use with adequate ventilation. NIOSH approved equipment should be worn if PELs are exceeded.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
9. PHYSICAL DATA
Appearance and Odor: Dark yellow liquid material. Odorless.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: 1.06
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility(ies): Not available.
Viscosity: Not available.
10. REACTIVITY DATA
Stability: Stable under normal conditions.
Conditions to Avoid: Heat.
Incompatibility (Materials to Avoid): Strong oxidizing and bases.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide
Hazardous Polymerization: Will not occur.
11. TOXICITY DATA
LD50 Oral - Rat - > 63,840 mg/kg
Carcinogenicity: No product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC, NTP, ACGIH & OSHA.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.
12. ECOLOGICAL DATA
Toxicity: Avoid release into the environment.
Persistence and Degradability: No information available.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.
13. DISPOSAL INFORMATION
Waste Disposal Methods: Dispose in accordance with all applicable Federal, State and Local regulations.
14. TRANSPORT INFORMATION
DOT USA, TDG Canada & ADR/RID Europe: Not controlled.
IMDG: Not controlled.
IATA: Not controlled.
15. REGULATORY INFORMATION
USA:
SARA 311/312 Hazards: See section 2.
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.
DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.
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Polysorbate 80 Structure
CAS Number 9005-65-6, Polysorbate 80 Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 11-dec-24
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