CAS Number 57-55-6, Propylene Glycol USP BP Ph Eur FCC Food Grade Manufacturers Exporters
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CAS Number 57-55-6, Propylene Glycol Manufacturer Exporter
For Properties Specifications of Propylene Glycol Click Properties, Specifications of Propylene Glycol Manufacturer.
For Uses of Propylene Glycol Click Uses of Propylene Glycol Manufacturer.
For For SDS MSDS Sheet of Propylene Glycol Click SDS Safety Data Sheet MSDS Sheet of Propylene Glycol Manufacturer.
The Properties and Specifications of Propylene Glycol:
Propylene Glycol USP Grade Specifications
C3H8O2 76.09
1,2-Propanediol.
1,2-Propanediol CAS 57-55-6
Propylene Glycol contains not less than 99.5 percent of C3H8O2.
Identification: Infrared Absorption 1on undried specimen.
Specific gravity: between 1.035 and 1.037.
Acidity: Add 1 mL of phph to 50 mL of water, then add 0.1 N sodium hydroxide until the solution remains pink for 30 seconds. Then add 10 mL of Propylene Glycol, accurately measured, and titrate with 0.10 N sodium hydroxide until the original pink color returns and remains for 30 seconds: not more than 0.20 mL of 0.10 N sodium hydroxide is required.
Water: not more than 0.2%.
Residue on ignition: Heat 50 g in a tared 100-mL shallow dish until it ignites, and allow it to burn without further application of heat in a place free from drafts. Cool, moisten the residue with 0.5 mL of sulfuric acid, and ignite to constant weight: the weight of the residue does not exceed 3.5 mg.
Chloride: A 1-mL portion shows no more chloride than corresponds to 0.10 mL of 0.020 N hydrochloric acid (0.007%).
Sulfate: A 5.0-mL portion shows no more sulfate than corresponds to 0.30 mL of 0.020 N sulfuric acid (0.006%).
Heavy metals: Mix 4.0 mL with water to make 25 mL: the limit is 5 ppm.
Propylene Glycol BP Ph Eur Grade Specifications
Ph Eur C3H8O2 -- 76.1 -- CAS 57-55-6
Action and use: Excipient.
DEFINITION
Propylene glycol is (RS)-propane-1,2-diol.
CHARACTERS
A viscous, clear, colourless, hygroscopic liquid, miscible with water and with ethanol (96 per cent).
IDENTIFICATION
A. It complies with the test for relative density.
B. It complies with the test for refractive index.
C. Boiling point: 184C to 189C.
D. To 0.5 ml add 5 ml of pyridine and 2 g of finely ground nitrobenzoyl chloride. Boil for 1 min and pour into 15 ml of cold water with shaking. Filter, wash the precipitate with 20 ml of a saturated solution of sodium hydrogen carbonate and then with water and dry. Dissolve in boiling ethanol (80 per cent V/V) and filter the hot solution. On cooling, crystals are formed which, after drying at 100-105C, melt at 121C to 128C.
TESTS
Appearance: It is clear and colourless.
Relative density: 1.035 to 1.040.
Refractive index: 1.431 to 1.433.
Acidity: To 10 ml add 40 ml of water R and 0.1 ml of bromothymol blue solution. The solution is greenish-yellow. Not more than 0.05 ml of 0.1 M sodium hydroxide is required to change the colour of the indicator to blue.
Oxidising substances: To 10 ml add 5 ml of water, 2 ml of potassium iodide solution and 2 ml of dilute sulphuric acid and allow to stand in a ground-glass-stoppered flask protected from light for 15 min. Titrate with 0.05 M sodium thiosulphate, using 1 ml of starch solution as indicator. Not more than 0.2 ml of 0.05 M sodium thiosulphate is required.
Reducing substances: To 1 ml add 1 ml of dilute ammonia and heat in a water-bath at 60C for 5 min. The solution is not yellow. Immediately add 0.15 ml of 0.1 M silver nitrate and allow to stand for 5 min. The solution does not change its appearance.
Heavy metals: 5 ppm m/V.
Water: Not more than 0.2 per cent, determined on 5.00 g by the semi-micro determination of water.
Sulphated ash: Heat 50 g until it burns and ignite. Allow to cool. Moisten the residue with sulphuric acid and ignite; repeat the operations. The residue weighs not more than 5 mg (0.01 per cent).
Polypropylene Glycol FCC Food Grade Specifications
CAS 25322-69-4
DESCRIPTION
Polypropylene Glycol occurs as a clear, colorless or practically colorless, viscous liquid. It is an addition polymer of propylene glycol and water represented by the formula HO(C3H6O)n- C3H6OH, in which n represents the average number of oxypropylene groups. It is soluble in water and in such organic solvents as aliphatic ketones and alcohols, but it is insoluble in ether and in most aliphatic hydrocarbons.
Function: Defoaming agent.
REQUIREMENTS
Lead:Not more than 1 mg/kg.
Nominal Molecular Weight: Not less than 90.0% and not more than 110.0% of the labeled value.
pH: Between 6.0 and 9.0.
Propylene Oxide: Not more than 0.02%.
Residue on Ignition: Not more than 0.01%.
Viscosity: Passes test.
The Uses of Propylene Glycol:
Propylene Glycol is used to absorb extra water and maintain moisture in certain medicines, cosmetics, or food products. It is a solvent for food colors and flavors, and in the paint and plastics industries. Propylene glycol is also used to create artificial smoke or fog used in fire-fighting training and in theatrical productions. Propylene glycol is used as a solvent in many pharmaceuticals, including oral, injectable, and topical formulations. Propylene glycol is commonly used as an additive to aid in the processing of foods and improve their texture, flavor, appearance and shelf life. It is also used as a drug stabiliser and as a solvent. food manufacturers also use propylene glycol as an emulsifier, a texturizer, etc. It is commonly used in many different foods including ice-cream, beverages, and different types of bread. It is used in food processing as the E-number E1520.
The MSDS-SDS Hazard Statement of Propylene Glycol:
Propylene Glycol SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 18-Jan-23
1. PRODUCT DESCRIPTION
Product Name & Other Names: Propylene Glycol or 1,2-Propanediol.
CAS Number: 57-55-6
EINECS EC Number: 200-338-0
Molecular Weight: 76.09
Molecular Formula: CH3CH(OH)CH2OH
Relevant uses and uses advised against (if any): Industrial Manufacturing.
2. HAZARD IDENTIFICATION
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Hazard Class and Category Code(s), Regulation (EC) No 1272/2008 (CLP)
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling as per GHS & Regulation EC 1272/2008 (CLP) & GHS
GHS Label Elements None |
Signal Words: None
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Product Name & Other Names: Propylene Glycol or 1,2-Propanediol.
CAS Number: 57-55-6
EINECS EC Number: 200-338-0
4. FIRST AID MEASURES
Always get medical attention after the first aid is over.
Emergency and First Aid Procedures:
Eyes - Flush with water for at least 15 minutes, raising and lowering eyelids occasionally. Get medical attention if irritation persists.
Skin - Thoroughly wash exposed area for at least 15 minutes. Remove contaminated clothing. Launder contaminated clothing before reuse. Get medical attention if irritation persists.
Ingestion - If it is swallowed, if conscious, give plenty of water. Immediately call a physician. Never give anything by mouth to an unconscious person.
Inhalation - Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Get medical attention.
5. FIREFIGHTING PROCEDURES
Extinguisher Media: Use media suitable to extinguish surrounding fire. Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture: Carbon oxides and fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used.
6. SPILL OR LEAK PROCEDURES
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc). Do not approach facing the wind.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep up and remove to an approved disposal container.
7. SPECIAL PRECAUTIONS
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like acid chlorides, acid anhydrides, oxidizing agents, chloroformates, reducing agents.
8. SPECIAL PROTECTION INFORMATION
Respiratory Protection (Specify Type): None needed under normal conditions of use with adequate ventilation. NIOSH approved equipment should be worn if PELs are exceeded.
Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
9. PHYSICAL DATA
Appearance and Odor: Clear viscous liquid. Odor not defined.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: 1.04
Melting Point: -60C
Boiling Point: 187C
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility(ies): Soluble in water.
Viscosity: Not available.
10. REACTIVITY DATA
Stability: It is stable
Conditions to Avoid: Heat, Dust generation.
Incompatibility (Materials to Avoid): Acid chlorides, Acid anhydrides, Oxidizing agents, Chloroformates, Reducing agents.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, fumes.
Hazardous Polymerization: Will not occur.
11. TOXICITY DATA
Acute toxicity:
LD50 Oral - Rat - 20,000 mg/kg
LD50 Dermal - Rabbit - 20,800 mg/kg
LD50 Intramuscular - Rat - 14 g/kg
LD50 Intravenous - Dog - 26 g/kg
Carcinogenicity: This product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC, NTP, ACGIH & OSHA.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.
12. ECOLOGICAL DATA
Toxicity to fish: mortality NOEC - Pimephales promelas (fathead minnow) - 52,930 mg/l - 96 h.
Toxicity to daphnia and other aquatic invertebrates: mortality NOEC - Daphnia (water flea) - 13,020 mg/l -48 h
EC50 - Daphnia magna (Water flea) - > 10,000 mg/l - 48 h
Bioaccumulative potential: Does not bioaccumulate.
Mobility: No information available.
Results of PBT and vPvB assessment: No data available for assessment.
13. DISPOSAL INFORMATION
Waste Disposal Methods: Dispose in accordance with all applicable Federal, State and Local regulations.
14. TRANSPORT INFORMATION
DOT USA, TDG Canada & ADR/RID Europe: Not controlled.
IMDG/IMO: Not controlled.
IATA: Not controlled.
15. REGULATORY INFORMATION
USA:
SARA 311/312 Hazards: See section 2.
California Prop. 65 Components: Not listed.
DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.
Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Propylene Glycol Structure
CAS Number 57-55-6, Propylene Glycol Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 10-dec-24
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