CAS Number 106463-17-6, Tamsulosin Hydrochloride or Tamsulosin HCl IP BP Ph Eur USP JP EP Grade Manufacturers Exporters
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CAS Number 106463-17-6, Tamsulosin Hydrochloride or Tamsulosin HCl IP BP Ph Eur USP EP JP Manufacturer Exporter
For Properties Specifications of Tamsulosin Hydrochloride or Tamsulosin HCl Click Properties, Specifications of Tamsulosin Hydrochloride or Tamsulosin HCl Manufacturer.
For Uses of Tamsulosin Hydrochloride or Tamsulosin HCl Click Uses of Tamsulosin Hydrochloride or Tamsulosin HCl Manufacturer.
For For SDS MSDS Sheet of Tamsulosin Hydrochloride or Tamsulosin HCl Click SDS Safety Data Sheet MSDS Sheet of Tamsulosin Hydrochloride or Tamsulosin HCl Manufacturer.
The Properties and Specifications of Tamsulosin Hydrochloride or Tamsulosin HCl:
Tamsulosin Hydrochloride BP Ph Eur Grade:
C20H29ClN2O5S --- 445.0 CAS 106463-17-6
Action and use: Alpha-1-adrenoceptor antagonist.
DEFINITION
5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride.
Content: 98.5 per cent to 101.0 per cent (dried substance).
CHARACTERS
Appearance: White or almost white powder.
Solubility: Slightly soluble in water, freely soluble in formic acid, slightly soluble in anhydrous ethanol.
Melting Point: About 230C.
IDENTIFICATION
Carry out either tests A, C, D or tests A, B, D.
A. Infrared absorption spectrophotometry.
B. Specific optical rotation: -20.5 to -17.5 (dried substance).
C. Enantiomeric purity.
D. Dissolve with heating 0.75 g in water and dilute to 100.0 mL with the same solvent. Take 5 mL of the solution and cool in an ice-bath. Add 3 mL of dilute nitric acid and shake. Allow to stand at room temperature for 30 min and filter. The filtrate gives reaction of chlorides.
TESTS
Related substances: To pass the test by liquid chromatography.
Enantiomeric purity: To pass the test by liquid chromatography.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105C for 2 h.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Tamsulosin Hydrochloride USP Grade Specifications:
C20H28N2O5S-HCI --- 444.97
Benzenesulfonamide, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, monohydrochloride, (R)-;
(−)-(R)-5-[2-[[2-(o-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide monohydrochloride
CAS 106463-17-6
UNII: 11SV1951MR
UNII: G3P28OML5I
DEFINITION
Tamsulosin Hydrochloride contains NLT 98.0% and NMT 102.0% of tamsulosin hydrochloride (C20H28N2O5S-HCl), calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption
B. Identification Tests—General, Chloride
C. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
Residue on Ignition: NMT 0.1%
Organic Impurities, Procedure 1: To pass the test by chromatography.
Organic Impurities, Procedure 2: To pass the test by chromatography.
Enantiomeric Purity: To pass the test by chromatography.
Loss on Drying: Dry at 105C for 2 h. Acceptance criteria: NMT 0.5%
We also manufacture Tamsulosin Hydrochloride JP IP EP Grade.
The Uses of Tamsulosin Hydrochloride or Tamsulosin HCl:
Tamsulosin Hydrochloride is used to relieve symptoms of urinary obstruction caused by enlarged prostate.
The MSDS-SDS Hazard Statement of Tamsulosin Hydrochloride or Tamsulosin HCl:
Tamsulosin Hydrochloride SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 14-nov-24
1. Product Identification
Product Name & Other Names: >Tamsulosin Hydrochloride.
CAS No.: 106463-17-6
EINECS EC Number: 629-756-5
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, oral Category 4, H302
Skin corrosion/irritation Category 2, H315
Serious eye damage/eye irritation Category 2A, H319
Specific target organ toxicity, single exposure; Respiratory tract irritation Category 3, H335
Labeling according to Regulation (EC) No 1272/2008
GHS Label Elements  Irritant Harmful |
Signal Words: Warning
Hazard statements:
H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P270: Do not eat, drink or smoke when using this product.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P332+313: If skin irritation occurs: Get medical advice/attention.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+313: If skin irritation occurs: Get medical advice/attention.
P337+P313 If eye irritation persists: Get medical advice/ attention.
3. Composition/Information on Ingredients
Product Name & Other Names: Tamsulosin Hydrochloride.
CAS No.: 106463-17-6
EINECS EC Number: 629-756-5
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep person warm and quiet; get medical attention.
Ingestion: Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact: Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention if irritation develops.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention.
5. Fire Fighting Measures
Fire: May become a fire hazard at high temperatures.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Avoid solid water jet as it can scatter the fire.
Special hazards arising from the substance or mixture: Carbon oxides, Nitrogen oxides (NOx), Sulfur oxides, Hydrogen chloride gas, Fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Avoid dust formation and control ignition sources. Storage: Room Temperature.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: None established.
Ventilation System: In general, dilution ventilation is a satisfactory health hazard control for this substance.
Personal Respirators (NIOSH Approved): Not expected to require personal respirator usage. For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn.
Skin Protection: >Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: White to beige powder.
Odor: No data found.
Odor threshold: No data found.
pH: No data found.
Relative density: No data found.
Boiling Point: Decomposes.
Melting Point: 595.5C literature.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Soluble in DMSO, methanol, and water.
Viscosity: No data found.
10. Stability and Reactivity
Stability: It is stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: May produce oxides of nitrogen, sulfur and carbon along with chlorine compounds and fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Heat, flame, ignition sources, dusting and incompatibles.
11. Toxicological Information
650 mg/kg LD50 oral rat.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Germ cell mutagenicity: No data found.
Reproductive toxicity: No data found.
12. Ecological Information
Toxicity: No data available.
Persistence and degradability: Unlikely to persist due to water solubility.
Bioaccumulative potential: Unlikely to accumulate due to water solubility.
Mobility: Likely to be mobile due to water solubility.
Results of PBT and vPvB assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
IATA/ICAO: Not dangerous goods.
IMDG/IMO: Not dangerous goods.
15. Regulatory Information
USA:
SARA 311/312 Hazardous Categorization: See section 2.
California Proposition 65: Not listed.
16. Other Information
DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.
Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Tamsulosin Hydrochloride or Tamsulosin HCl Structure
CAS Number 106463-17-6, Tamsulosin Hydrochloride or Tamsulosin HCl Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 18-nov-24
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