CAS Number 99300-78-4, Venlafaxine Hydrochloride USP IP BP Ph Eur JP Grade Manufacturers Exporters
------ 
CAS Number 99300-78-4, Venlafaxine Hydrochloride USP IP BP Ph Eur JP Manufacturer Exporter
For Properties Specifications of Venlafaxine Hydrochloride Click Properties, Specifications of Venlafaxine Hydrochloride Manufacturer.
For Uses of Venlafaxine Hydrochloride Click Uses of Venlafaxine Hydrochloride Manufacturer.
For For SDS MSDS Sheet of Venlafaxine Hydrochloride Click SDS Safety Data Sheet MSDS Sheet of Venlafaxine Hydrochloride Manufacturer.
The Properties and Specifications of Venlafaxine Hydrochloride:
Venlafaxine Hydrochloride BP Ph Eur Grade:
C17H28ClNO2 --- 313.9 CAS 99300-78-4
Action and use: Inhibition of 5HT and noradrenaline reuptake; antidepressant.
DEFINITION
1-[(1RS)-2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride.
Content: 99.0 per cent to 101.0 per cent (dried substance).
CHARACTERS
Appearance: White or almost white powder.
Solubility: Freely soluble in water and in methanol, soluble in anhydrous ethanol, slightly soluble or practically insoluble in acetone. It shows polymorphism.
IDENTIFICATION
A. Infrared absorption spectrophotometry.
B. It gives reaction of chlorides.
TESTS
Acidity or alkalinity: Dissolve 0.20 g in carbon dioxide-free water and dilute to 10 mL with the same solvent. Add 0.05 mL of methyl red solution and 0.1 mL of 0.01 M hydrochloric acid. The solution is pink. Not more than 0.2 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to yellow.
Related substances: To pass the test by Liquid chromatography.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in vacuo at 80C for 3 h.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Venlafaxine Hydrochloride USP Grade Speicifications:
C17H27NO2-HCl --- 313.86
Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, hydrochloride;
(±)-1-[α-[(Dimethylamino)methyl]-p-methoxybenzyl]cyclohexanol hydrochloride
CAS 99300-78-4
UNII: 7D7RX5A8MO
UNII: GRZ5RCB1QG
DEFINITION
Venlafaxine Hydrochloride contains NLT 98.0% and NMT 102.0% of venlafaxine hydrochloride (C17H27NO2-HCl), calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption
B. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
C. Identification Tests—General, Chloride: Meets the requirements
Residue on Ignition: NMT 0.1%
Organic Impurities: To pass the test by chromatography.
Loss on Drying: Dry under vacuum at 105C for 3 h. Acceptance criteria: NMT 0.5%
Packaging and Storage: Preserve in well-closed containers, and store at controlled room temperature.
We also manufacture Venlafaxine Hydrochloride JP IP Grade.
The Uses of Venlafaxine Hydrochloride:
Venlafaxine Hydrochloride is used to treat depression. It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.
The MSDS-SDS Hazard Statement of Venlafaxine Hydrochloride:
Venlafaxine Hydrochloride or Venlafaxine HCL SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 18-Nov-24
Section 1: Product and Company Identification
Product Name & Other Names: Venlafaxine Hydrochloride or Venlafaxine HCL.
CAS No.: 99300-78-4
EINECS, EC Number: 200-659-6
Relevant uses and uses advised against (if any): Laboratory chemicals, Manufacture of substances
Supplier: As per letterhead.
Section 2: Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Specific target organ toxicity - repeated exposure (Category 1), H372
Chronic aquatic toxicity (Category 2), H411
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements  Health Hazard |
GHS Label Elements |
Signal Words: Danger
Hazard statements:
H372 Causes damage to organs through prolonged or repeated exposure.
H410: Toxic to aquatic life with long lasting effects.
Precautionary statements:
P202: Do not handle until all safety precautions have been read and understood.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
P342+311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
Section 3: Composition / Information on Ingredients
Product Name & Other Names: Venlafaxine Hydrochloride or Venlafaxine HCL.
CAS No.: 99300-78-4
EINECS, EC Number: 200-659-6
Section 4: First Aid Measures
Always seek medical attention after first aid measures are provided.
Eyes: Immediately flush eyes with excess water for 15 minutes, lifting lower and upper eyelids occasionally.
Skin: Immediately flush skin with excess water for 15 minutes while removing contaminated clothing.
Ingestion: Call Emergency Medical immediately. Rinse mouth with cold water. Give the victim 1-2 cups of water or milk to drink. Induce vomiting immediately.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration.
Section 5: Fire Fighting Measures
It is a non-flammable solid. However, it can burn at high temperature.
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Avoid solid water jet as it can scatter the fire.
Protective equipment and precautions for firefighters: Use water spray, foam, or dry chemical to extinguish fire. Firefighters should wear full firefighting turn-out gear and respiratory protection. Cool container with water spray.
Special hazards arising from the substance: Hydrogen chloride, carbon oxides, nitrogen oxide and fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
Section 6: Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.
Section 7: Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Room Temperature. Light Sensitive.
Section 8: Exposure Controls / Personal Protection
Exposure guidelines: This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
Section 9: Physical and Chemical Properties
Physical state and appearance: White to almost white powder or crystal.
Odor: No data found.
Odor threshold: No data found.
pH (1% soln/water): No data found.
Relative density: No data found.
Melting Point: 217C literature.
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Soluble in methanol.
Viscosity: No data found.
Section 10: Stability and Reactivity
Avoid heat and ignition sources.
Stability: Stable under normal conditions of use and storage.
Incompatibility: Heat and strong oxidizing agents. Heat.
Hazardous Decomposition Products: Hydrogen chloride, carbon oxides, nitrogen oxide and fumes.
Hazardous Polymerization: Has not been reported.
Section 11: Toxicology Information
LD50 Oral Rat No information found.
Acute inhalation toxicity: LC50, 4 h, Rat, 4.47 mg/l
Carcinogenicity: No data found.
Reproductive toxicity: No data found.
Developmental Effects: No data found.
Teratogenicity: No data found.
Section 12: Ecological Information
Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna (Water flea) - 38 mg/l - 48 h.
Ecotoxicity (aquatic and terrestrial): Toxic to aquatic life with long lasting effects.
Persistence and Degradability: No data found.
Mobility: No data found.
Results of PBT and vPvB assessment: No data found.
Section 13: Disposal Considerations
Check with all applicable local, regional, and national laws and regulations. Follow all th pollution control laws.
Section 14: Transport Information
DOT USA and ADR/RID Europe:
UN-No: UN3077
Proper Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
Proper technical name: ((Venlafaxine hydrochloride)
Hazard Class: 9; Packing Group: III.
TDG:
UN-No: UN3077
Proper Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
Proper technical name: ((Venlafaxine hydrochloride)
Hazard Class: 9; Packing Group: III.
IATA
UN-No: UN3077
Proper Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
Proper technical name: ((Venlafaxine hydrochloride)
Hazard Class: 9; Packing Group: III.
IMDG/IMO
UN-No: UN3077
Proper Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
Proper technical name: ((Venlafaxine hydrochloride)
Hazard Class: 9; Packing Group: III.
Section 15: Regulatory Information
USA:
SARA 313 Components: Not Listed
SARA 311/312 Hazard Categories: Acute Health Hazard, Chronic Health Hazard
California Proposition 65: Not listed by California Proposition 65 to cause any harm by cancer or birth defects, or any other reproductive harm..
Section 16: Other Information
DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.
Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Venlafaxine Hydrochloride Structure
CAS Number 99300-78-4, Venlafaxine Hydrochloride Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 11-dec-24
We manufacture:
Chlorhexidine Hydrochloride or Chlorhexidine Dihydrochloride or Chlorhexidine
Esmolol Hydrochloride or Esmolol HCl
Fexofenadine HCl or Fexofenadine Hydrochloride
Fingolimod Hydrochloride or Fingolimod HCl
Nebivolol Hydrochloride or Nebivolol HCl
Paroxetine HCl or Paroxetine Hydrochloride
Phenazopyridine Hydrochloride or Phenazopyridine HCl
Pioglitazone Hydrochloride or Pioglitazone HCl