CAS Number 3697-42-5, Chlorhexidine Hydrochloride or Chlorhexidine Dihydrochloride or Chlorhexidine HCl USP BP Ph Eur IP JP EP Grade Manufacturers Exporters

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Chlorhexidine Hydrochloride or Chlorhexidine Dihydrochloride Manufacturers Exporters
CAS Number 3697-42-5, Chlorhexidine Hydrochloride or Chlorhexidine Dihydrochloride or Chlorhexidine HCl USP BP Ph Eur IP JP EP Manufacturer Exporter

For Properties Specifications of Chlorhexidine Hydrochloride or Chlorhexidine Dihydrochloride or Chlorhexidine HCl USP BP Ph Eur IP JP EP Click Properties, Specifications of Chlorhexidine Hydrochloride or Chlorhexidine Dihydrochloride or Chlorhexidine HCl USP BP Ph Eur IP JP EP Manufacturer.

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The Properties and Specifications of Chlorhexidine Hydrochloride or Chlorhexidine Dihydrochloride or Chlorhexidine HCl USP BP Ph Eur IP JP EP:

Chlorhexidine Hydrochloride BP Ph Eur Grade:
C22H32Cl4N10 --- 578.4 CAS 3697-42-5
Action and use: Antiseptic.

DEFINITION
1,1′-(Hexane-1,6-diyl)bis[5-(4-chlorophenyl)biguanide] dihydrochloride.
Content: 98.0 per cent to 101.0 per cent (dried substance).

CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Very slightly soluble in water, slightly soluble in propylene glycol, very slightly soluble in ethanol (96 per cent).

IDENTIFICATION
First identification: A, D.
Second identification: B, C, D.
A. Infrared absorption spectrophotometry.
B. Dissolve about 5 mg in 5 mL of a warm 10 g/L solution of cetrimide and add 1 mL of strong sodium hydroxide solution and 1 mL of bromine water. A dark red colour is produced.
C. Dissolve 0.3 g in 10 mL of a mixture of equal volumes of hydrochloric acid and water. Add 40 mL of water, filter if necessary and cool in iced water. Make alkaline to titan yellow paper by adding dropwise, and with stirring, strong sodium hydroxide solution and add 1 mL in excess. Filter, wash the precipitate with water until the washings are free from alkali and recrystallize from ethanol (70 per cent V/V). Dry at 100-105C. The residue melts at 132C to 136C.
D It gives reaction of chlorides.

TESTS
Impurity P (chloroaniline): Maximum 300 ppm.
Related substances: To pass the test by Liquid chromatography.
Loss on drying: Maximum 1.0 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.


Chlorhexidine Hydrochloride USP Grade Specifications:
C22H30Cl2N10-2HCl --- 578.37
2,4,11,13-Tetraazatetradecanediimidamide, N,N ′ ′-bis(4-chlorophenyl)-3,12-diimino-, dihydrochloride;
1,1′-Hexamethylenebis[5-(p-chlorophenyl)biguanide] dihydrochloride CAS 3697-42-5
UNII: E64XL9U38K
UNII: R4KO0DY52L

DEFINITION
Chlorhexidine Hydrochloride contains NLT 98.0% and NMT 102.0% of chlorhexidine hydrochloride (C22H30Cl2N10-2HCl), calculated on the dried basis.

IDENTIFICATION
A
. Infrared Absorption.
B. Identification Tests—General, Chloride.

Residue on Ignition: NMT 0.1%
Organic Impurities: To pass the test.
Limit of p-Chloroaniline: To pass the test. NMT 500 ppm.
Loss on Drying: Dry at 105C to constant weight. Loss NMT 1.0%
Packaging and Storage: Preserve in well-closed, light-resistant containers.


We also supply Chlorhexidine Hydrochloride or Chlorhexidine Dihydrochloride IP JP EP Grade.


The Uses of Chlorhexidine Hydrochloride or Chlorhexidine Dihydrochloride or Chlorhexidine HCl USP BP Ph Eur IP JP EP:

Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms.


The MSDS-SDS Hazard Statement of Chlorhexidine Hydrochloride or Chlorhexidine Dihydrochloride or Chlorhexidine HCl USP BP Ph Eur IP JP EP:

Chlorhexidine Hydrochloride or Chlorhexidine dihydrochloride or Chlorhexidine HCl
SDS GHS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
 02-Nov-24

Section 1: Chemical Product and Company Identification

Product Name & Other Names: Chlorhexidine Hydrochloride or Chlorhexidine dihydrochloride or Chlorhexidine HCl.
CAS Number
: 3697-42-5
EINECS EC Code: 223-026-6 or 200-238-7
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

Section 2: Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Hazard Class and Category Code(s), Regulation (EC) No 1272/2008 (CLP)

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Labeling Regulation as per GHS & EC 1272/2008 (CLP) & GHS

GHS Label Elements
NONE

Signal Word: None

Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Section 3: Composition and Information on Ingredients

Product Name & Other Names: Chlorhexidine Hydrochloride or Chlorhexidine dihydrochloride or Chlorhexidine HCl.
CAS Number
: 3697-42-5
EINECS EC Code: 223-026-6 or 200-238-7

Section 4: First Aid Measures

Always seek medical advice after the first aid treatment.

Skin: Rinse with water. Soap may be used. Seek Medical Aid.
Eyes: Wash eyes with plenty of water for at least 15 minutes, lifting lids occasionally. Seek Medical Aid.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion: If swallowed, induce vomiting immediately after giving two glasses of water. Never give anything by mouth to an unconscious person.

Section 5: Fire and Explosion Data

Fire: Not a fire hazard. However, it can burn at high temperature.
Products of Combustion: Fumes and Oxides of Carbon and Nitrogen. Hydrogen chloride and complex chlorine compounds may also evolve.
Fire Fighting Media and Instructions: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary. Avoid solid water jet.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Section 6: Accidental Release Measures

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to legal requirements.
Large Spill: Contain spilled material. Do not inhale vapors, mist, or gas. Avoid dust formation. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and disposing of it according to legal requirements.

Section 7: Handling and Storage

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents and bases. Storage: Refrigerator. Short term shipping may be ambient.

Section 8: Exposure Controls/Personal Protection

Occupational Exposure Limits: This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume, or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Section 9: Physical and Chemical Properties

Physical state and appearance: White or almost white, crystalline powder.
Odor: No data found.
Odor threshold: No data found.
pH: No data found.
Relative density: No data found.
Melting point/freezing point: 134C literature.
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: No data found.
Viscosity: No data found.
Molecular Formula: C22H30Cl2N10-2HCl
Molecular Weight: 578.37

Section 10: Stability and Reactivity Data

Stability: It is stable at recommended storage temperature closed containers under normal storage & handling.
Hazardous decomposition products: Fumes and Oxides of Carbon and Nitrogen. Hydrogen chloride and complex chlorine compounds may also evolve
Conditions of instability: Incompatible materials, heat flame.
Incompatibility with various substances: Avoid high temperatures, sparks, open flames, and moisture. Avoid contact with strong oxidizing agents and bases.
Polymerization: Will not occur.

Section 11: Toxicological Information

LD50 Oral – Rat: No data found.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Mutagenic Effects: No data found.
Developmental Toxicity: No data found.
Reproductive Effects: No data found.

Section 12: Ecological Information

Toxicity to fish: No data found.
Persistence and Degradability: Unlikely to persist.
Mobility: Likely to be mobile.
Bioaccumulation/ Accumulation: Degradable.
Results of PBT and vPvB assessment: No data available for assessment.

Section 13: Disposal Considerations

Waste Disposal: Waste must be disposed of in accordance with federal, state, and local environmental control regulations.

Section 14: Transport Information

DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IMDG/IMO & IATA/ICAO: Not regulated.

Section 15: Other Regulatory Information

USA Regulations:
SARA 311/312 Hazard Categories: Not applicable. See section 2.
California Prop 65: Not listed.

Section 16 - Additional Information

DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.

Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.

Chlorhexidine Hydrochloride or Chlorhexidine Dihydrochloride Suppliers
Chlorhexidine Hydrochloride or Chlorhexidine Dihydrochloride or Chlorhexidine HCl Structure

CAS Number 3697-42-5, Chlorhexidine Hydrochloride or Chlorhexidine Dihydrochloride or Chlorhexidine HCl Manufacturer Exporter

ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA

e-mail: info(At the rate i.e. @)anmol.org

Copyright. 2-nov-24

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