CAS Number 5026-62-0, Sodium Methylparaben or Sodium Methyl Hydroxybenzoate USP NF BP Ph Eur Grade Manufacturers Exporters
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CAS Number 5026-62-0, Sodium Methylparaben or Sodium Methyl Hydroxybenzoate Manufacturer Exporter
For Properties Specifications of Sodium Methylparaben or Sodium Methyl Hydroxybenzoate Click Properties, Specifications of Sodium Methylparaben or Sodium Methyl Hydroxybenzoate Manufacturer.
For Uses of Sodium Methylparaben or Sodium Methyl Hydroxybenzoate Click Uses of Sodium Methylparaben or Sodium Methyl Hydroxybenzoate Manufacturer.
For For SDS MSDS Sheet of Sodium Methylparaben or Sodium Methyl Hydroxybenzoate Click SDS Safety Data Sheet MSDS Sheet of Sodium Methylparaben or Sodium Methyl Hydroxybenzoate Manufacturer.
The Properties and Specifications of Sodium Methylparaben or Sodium Methyl Hydroxybenzoate:
Methylparaben Sodium USP NF Grade
Methylparaben Sodium contains not less than 98.5 percent and not more than 101.5 percent of C8H7NaO3, calculated on the anhydrous basis.
Completeness of solution: One g of it, dissolved in water, meets the requirement.
Identification:
A: Dissolve 0.5 g in 5 mL of water, acidify with hydrochloric acid, and filter the resulting precipitate. Wash the precipitate with water, and dry it over silica gel for 5 hours: the IR absorption spectrum of a mineral oil dispersion of it exhibits maxima only at the same wavelengths as that of a similar preparation of USP Methylparaben.
B: Ignite about 0.3 g, cool, and dissolve the residue in about 3 mL of 3 N hydrochloric acid. A platinum wire dipped in this solution imparts an intense, persistent yellow color to a nonluminous flame.
pH: between 9.5 and 10.5, in a solution (1 in 1000).
Water: not more than 5.0%.
Chloride: A 0.2-g portion shows no more chloride than corresponds to 0.10 mL of 0.020 N hydrochloric acid (0.035%).
Sulfate: A 0.25-g portion shows no more sulfate than corresponds to 0.30 mL of 0.020 N sulfuric acid (0.12%).
Sodium Methyl Hydroxybenzoate BP Ph Eur Grade Specifications
Sodium Methylparaben
Sodium Methyl Parahydroxybenzoate, Ph Eur
C8H7NaO3 --- 174.1 --- CAS 5026-62-0
Action and use: Antimicrobial preservative.
DEFINITION
Sodium methyl parahydroxybenzoate contains not less than 99.0 per cent and not more than the equivalent of 102.0 per cent of sodium 4-(methoxycarbonyl)phenolate, calculated with reference to the anhydrous substance.
CHARACTERS
A white or almost white, crystalline powder, freely soluble in water, sparingly soluble in alcohol, practically insoluble in methylene chloride.
IDENTIFICATION
First identification A, B, E.
Second identification A, C, D, E.
A. Dissolve 0.5 g in 50 ml of water. Immediately add 5 ml of hydrochloric acid. Filter and wash the precipitate with water. Dry under vacuum at 80C for 2 h. The precipitate obtained melts at 125C to 128C.
B. Examine the precipitate obtained in identification test A by infrared absorption spectrophotometry, comparing with the spectrum obtained with methyl parahydroxybenzoate CRS.
C. Examine the chromatograms obtained in the test for related substances. The principal spot in the chromatogram obtained with test solution (b) is similar in position and size to the principal spot in the chromatogram obtained with reference solution (c).
D. To about 10 mg in a test-tube add 1 ml of sodium carbonate solution, boil for 30 s and cool. Add 5 ml of aminopyrazolone solution and 1 ml of potassium ferricyanide solution and mix. An orange to red colour develops.
E. To 1 ml of solution S (see Tests) add 1 ml of water. The solution gives reaction (a) of sodium.
TESTS
Solution S: Dissolve 5.0 g in carbon dioxide-free water prepared from distilled water and dilute to 50 ml with the same solvent.
Appearance of solution: Solution S examined immediately after preparation is clear and not more intensely coloured than reference solution.
pH: Dilute 1 ml of solution S to 100 ml with carbon dioxide-free water. The pH of the solution is 9.5 to 10.5.
Related substances: To pass the test.
Chlorides: To 10 ml of solution S, add 30 ml of water and 1 ml of nitric acid and dilute to 50 ml with water. Shake and filter. Dilute 10 ml of the filtrate to 15 ml with water. The solution complies with the limit test for chlorides (350 ppm). Prepare the standard using 14 ml of chloride standard solution (5 ppm Cl) to which 1 ml of water has been added.
Sulphates: To 25 ml of solution S, add 5 ml of distilled water and 10 ml of hydrochloric acid and dilute to 50 ml with distilled water. Shake and filter. Dilute 10 ml of the filtrate to 15 ml with distilled water. The solution complies with the limit test for sulphates (300 ppm).
Heavy metals: 2.0 g complies with limit test C for heavy metals (10 ppm). Prepare the standard using 2 ml of lead standard solution (10 ppm Pb).
Water: Not more than 5.0 per cent, determined on 0.500 g by the semi-micro determination of water.
The Uses of Sodium Methylparaben or Sodium Methyl Hydroxybenzoate:
Methylparaben has been used as a preservative used in the food, cosmetic, and pharmaceutical industries for over 50 years. Sodium methyl paraben is widely used in food and pharmaceutical and textile industry for its antiseptic property. Sodium methyl paraben is also can be used in other industries such as cosmetics, feed and so on. It is a food additive with the E number E219 which is used as a preservative.
The MSDS-SDS Hazard Statement of Sodium Methylparaben or Sodium Methyl Hydroxybenzoate:
Sodium Metabisulfite or Sodium Metabisulphite SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 25-Jan-23
1. Product Identification
Product Name & Other Names: Sodium Metabisulfite or Sodium Metabisulphite or Disulfurous acid, Disodium salt or Fertisilo or Pyrosulfurous acid, disodium salt or Sodium disulfite or Disodium pyrosulfite or Sodium pyrosulfite.
CAS No.: 7681-57-4 Sodium Metabisulfite or Sodium Metabisulphite.
EINECS EC Number: 231-673-0
Molecular Weight: 190.11
Chemical Formula: Na2S2O5 (sodium metabisulfite)
Relevant uses and uses advised against (if any): Industrial Manufacturing.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, oral Category 4, H302
Acute toxicity, dermal Category 5, H315
Serious eye damage/eye irritation Category 1, H318
Labeling according to GHS USA & Regulation (EC) No 1272/2008
GHS Label Elements  Corrosive |
Signal Words: Danger
Hazard statements:
H302: Harmful if swallowed.
H315: Causes skin irritation.
H318: Causes serious eye damage.
EUH031: Contact with acids liberates toxic gas.
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P264 Wash with plenty of water and soap thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P281: Wear protective equipment for hands, eyes, face and respiratory tract.
P270: Do not eat, drink or smoke when using this product.
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+P313 : If skin irritation occurs: Get medical advice/attention.
3. Composition/Information on Ingredients
Product Name & Other Names: Sodium Metabisulfite or Sodium Metabisulphite or Disulfurous acid, Disodium salt or Fertisilo or Pyrosulfurous acid, disodium salt or Sodium disulfite or Disodium pyrosulfite or Sodium pyrosulfite.
CAS No.: 7681-57-4
EINECS EC Number: 231-673-0
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Fire: Not considered to be a fire hazard.
Fire Extinguishing Media: Use any means suitable for extinguishing surrounding fire. Do not allow water runoff to enter sewers or waterways.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Do not approach facing the wind.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, acids, alkalis, sodium nitrite, aluminum powder. Avoid moisture, water, ice.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: ACGIH Threshold Limit Value (TLV) 5mg/m3 (TWA)
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits.
Personal Respirators (NIOSH Approved): If the exposure limit is exceeded, a half-face respirator with an acid gas cartridge may be worn for up to ten times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron, or coveralls, as appropriate, to prevent skin contact. (neoprene, polyvinyl chloride).
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
9. Physical and Chemical Properties
Appearance: White to yellow white crystalline granules.
Odor: Slight odor of sulfur dioxide.
Odor threshold: Not available.
pH: Aqueous solution is acidic.
Relative density: around 1.48
Melting Point: 150C (302F).
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Very soluble in water, insoluble in alcohol.
Viscosity: Not available.
10. Stability and Reactivity
Stability: Product is normally stable. Air and moisture sensitive and releases sulfur dioxide slowly at ambient temperatures. Sodium Metabisulfite will decompose on heating to form sodium sulfate. Contact with moisture (water, wet ice, etc.), will release toxic sulfur dioxide gas.
Hazardous Decomposition Products: Oxides of sulfur and sodium may form when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Water, acids, alkalis, sodium nitrite, oxidizers, aluminum powder.
Conditions to Avoid: Moisture, heat, flames, ignition sources and incompatibles.
11. Toxicological Information
LD50 Oral - Rat - 1.540 mg/kg
LD50 Dermal - Rat - > 2.000 mg/kg
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.
12. Ecological Information
Toxicity to fish: LC50 - Oncorhynchus mykiss (rainbow trout) - 150 - 220 mg/l - 96 h
Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna (Water flea) - 89 mg/l - 24 h
Toxicity to algae: IC50 - Desmodesmus subspicatus (green algae) - 48 mg/l - 72 h
Toxicity to bacteria: Pseudomonas putida - 56 mg/l - 17 h
Results of PBT and vPvB assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe: Not controlled.
IMDG/IMO: Not controlled.
IATA/ICAO: Not controlled.
15. Regulatory Information
USA:
SARA 311/312: See section 2.
Section 16 - Additional Information
DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.
Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is an off-shoot of Anmol Chemicals Taloja. It is located in MIDC Taloja and it is manufacturing pharmaceutical grades of API, Excepients, Food grade and Reagent grade chemicals. Anmol Chemicals & Pharmaceuticals Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies for actual users, retail or small pack supplies for research and development chemicals, fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, Analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals, Mineral Fortifiers at best prices.
Sodium Methylparaben or Sodium Methyl Hydroxybenzoate Structure
CAS Number 5026-62-0, Sodium Methylparaben or Sodium Methyl Hydroxybenzoate Manufacturer Exporter
ANMOL CHEMICALS & PHARMACEUTICALS Pvt. Ltd.
India, USA, Europe, UAE
TELEPHONE: +912223770100
Navi Mumbai, INDIA
e-mail: info(At the rate i.e. @)anmol.org
Copyright. 12-nov-24
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